Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/77485
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Mapping and ablation of the pulmonary veins and cavo-tricuspid isthmus with a magnetic resonance imaging-compatible externally irrigated ablation catheter and integrated electrophysiology system
Author: Ganesan, A.
Selvanayagam, J.
Mahajan, R.
Grover, S.
Nayyar, S.
Brooks, A.
Finnie, J.
Sunnarborg, D.
Lloyd, T.
Chakrabarty, A.
Abed, H.
Sanders, P.
Citation: Circulation, Arrhythmia & Electrophysiology (Print), 2012; 5(6):1136-1142
Publisher: Lippincott Williams & Wilkins
Issue Date: 2012
ISSN: 1941-3149
1941-3084
Statement of
Responsibility: 
Anand N. Ganesan, Joseph B. Selvanayagam, Rajiv Mahajan, Suchi Grover, Sachin Nayyar, Anthony G. Brooks, John Finnie, Daniel Sunnarborg, Thomas Lloyd, Adhiraj Chakrabarty, Hany S. Abed, Prashanthan Sanders
Abstract: BACKGROUND—Magnetic resonance imaging (MRI)–guided interventional electrophysiology (EP) has rapidly emerged as a promising alternative to x-ray–guided ablation. We aimed to evaluate an externally irrigated MRI-compatible ablation catheter and integrated EP pacing and recording system, testing the feasibility of pulmonary vein and cavo-tricuspid isthmus ablation. METHODS AND RESULTS—Externally irrigated MRI-compatible ablation and diagnostic EP catheters and an integrated EP recording system (Imricor Medical Systems, Burnsville, MN) were tested in n=11 sheep in a 1.5-T MRI scanner. Power-controlled (40 W, 120-second duration) lesions were formed at the pulmonary vein and cavo-tricuspid isthmus. Real-time intracardiac electrograms were recorded during MRI. Steady-state free precession non–breath-hold images were repeatedly acquired to guide catheter navigation. Lesion visualization was performed using noncontrast (T2-weighted turbo spin echo pulse sequence) and gadolinium-diethylene triamine pentaacetic acid–enhanced T1-weighted imaging (inversion-recovery gradient echo pulse sequence). Catheters were able to be visualized and navigated under cardiovascular magnetic resonance guidance. In total, 8±2.5 lesions (radiofrequency time, 16±4.2 minutes) were formed at the pulmonary vein ostia, and 6.5±1.3 lesions (radiofrequency time, 13±2.2 minutes) were formed at the cavo-tricuspid isthmus, with the end point of bidirectional block. The mean procedure time was 150±55 minutes. Lesion visualization with both T2W imaging and contrast-enhanced imaging correlated with sites of injury at autopsy. CONCLUSIONS—These data demonstrate the feasibility of using multiple catheters, an integrated EP pacing and recording system, and externally irrigated ablation with cardiovascular magnetic resonance guidance to undertake clinically relevant biatrial mapping and ablation.
Keywords: ablation; catheter ablation; electrophysiology; magnetic resonance imaging
Rights: © 2012 American Heart Association, Inc.
RMID: 0020125748
DOI: 10.1161/CIRCEP.112.974436
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.