Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/76404
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Cetuximab in metastatic colorectal cancer |
Author: | Broadbridge, V. Karapetis, C. Price, T. |
Citation: | Expert Review of Anticancer Therapy: an essential contribution to decision making in cancer care, 2012; 12(5):555-565 |
Publisher: | Future Drugs Ltd. |
Issue Date: | 2012 |
ISSN: | 1473-7140 1744-8328 |
Statement of Responsibility: | Vy Tuong Broadbridge, Cristos S. Karapetis and Timothy Jay Price |
Abstract: | Management of metastatic colorectal cancer has evolved in the last 10 years, with the availability of targeted therapies resulting in improvement in quality of life and overall survival. Cetuximab is a chimeric monoclonal antibody that binds to the EGF receptor, and the net effects are inhibition of tumor growth, invasion, angiogenesis and metastasis. Cetuximab binding to the EGF receptor is also known to augment the effects of chemotherapy and radiotherapy. Only tumors expressing wild-type KRAS respond to cetuximab and improvements in progression-free survival and overall survival are seen, whereas patients with mutant KRAS are considered to be resistant. Cetuximab is currently available worldwide for use as monotherapy or in combination with chemotherapy in first-, second- or third-line settings in metastatic colorectal cancer patients with wild-type KRAS. |
Keywords: | Humans Colorectal Neoplasms Liver Neoplasms Camptothecin ras Proteins Proto-Oncogene Proteins Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Antibodies, Monoclonal Mutation Proto-Oncogene Proteins p21(ras) Antibodies, Monoclonal, Humanized ErbB Receptors Cetuximab Irinotecan |
Rights: | © 2012 Expert Reviews Ltd. |
DOI: | 10.1586/ERA.12.25 |
Published version: | http://dx.doi.org/10.1586/era.12.25 |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.