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https://hdl.handle.net/2440/76245
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Type: | Journal article |
Title: | Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies |
Author: | Schosser, A. Gaysina, D. Cohen-Woods, S. Chow, P. Martucci, L. Craddock, N. Farmer, A. Korszun, A. Gunasinghe, C. Gray, J. Jones, L. Tozzi, F. Perry, J. Muglia, P. Owen, M. Craig, I. McGuffin, P. |
Citation: | Molecular Psychiatry, 2010; 15(8):844-849 |
Publisher: | Nature Publishing Group |
Issue Date: | 2010 |
ISSN: | 1359-4184 1476-5578 |
Statement of Responsibility: | A Schosser, D Gaysina, S Cohen-Woods, PC Chow, L Martucci, N Craddock, A Farmer, A Korszun, C Gunasinghe, J Gray, L Jones, F Tozzi, J Perry, P Muglia, MJ Owen, IW Craig, and P McGuffin |
Abstract: | The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD). The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX-DISC1 fusion protein. We explored the TSNAX-DISC1 gene region for an association with BD and MDD in a sample of 1984 patients (1469 MDD, 515 BD) and 1376 ethnically matched controls. Eight single nucleotide polymorphisms (SNPs) within the TSNAX-DISC1 region (rs766288, rs3738401, rs2492367, rs6675281, rs12133766, rs1000731, rs7546310 and rs821597) were investigated using the SNPlex Genotyping System. We found a significant allelic and genotypic association of the TSNAX-DISC1 gene region with BD, whereas a haplotypic association was found for both BD and MDD. Therefore, our results suggest an association between the TSNAX-DISC1 region and both forms of affective disorders, and support the hypothesis that a portion of the genotypic overlap between schizophrenia and affective disorders is attributable to this gene. |
Keywords: | bipolar disorder depression association psychosis |
Rights: | © 2010 Macmillan Publishers Limited All rights reserved. |
DOI: | 10.1038/mp.2009.21 |
Published version: | http://dx.doi.org/10.1038/mp.2009.21 |
Appears in Collections: | Aurora harvest Psychiatry publications |
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