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|Title:||Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies|
|Citation:||Molecular Psychiatry, 2010; 15(8):844-849|
|Publisher:||Nature Publishing Group|
|A Schosser, D Gaysina, S Cohen-Woods, PC Chow, L Martucci, N Craddock, A Farmer, A Korszun, C Gunasinghe, J Gray, L Jones, F Tozzi, J Perry, P Muglia, MJ Owen, IW Craig, and P McGuffin|
|Abstract:||The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD). The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX-DISC1 fusion protein. We explored the TSNAX-DISC1 gene region for an association with BD and MDD in a sample of 1984 patients (1469 MDD, 515 BD) and 1376 ethnically matched controls. Eight single nucleotide polymorphisms (SNPs) within the TSNAX-DISC1 region (rs766288, rs3738401, rs2492367, rs6675281, rs12133766, rs1000731, rs7546310 and rs821597) were investigated using the SNPlex Genotyping System. We found a significant allelic and genotypic association of the TSNAX-DISC1 gene region with BD, whereas a haplotypic association was found for both BD and MDD. Therefore, our results suggest an association between the TSNAX-DISC1 region and both forms of affective disorders, and support the hypothesis that a portion of the genotypic overlap between schizophrenia and affective disorders is attributable to this gene.|
|Keywords:||bipolar disorder; depression; association; psychosis|
|Rights:||© 2010 Macmillan Publishers Limited All rights reserved.|
|Appears in Collections:||Psychiatry publications|
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