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Type: Journal article
Title: Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies
Author: Schosser, A.
Gaysina, D.
Cohen-Woods, S.
Chow, P.
Martucci, L.
Craddock, N.
Farmer, A.
Korszun, A.
Gunasinghe, C.
Gray, J.
Jones, L.
Tozzi, F.
Perry, J.
Muglia, P.
Owen, M.
Craig, I.
McGuffin, P.
Citation: Molecular Psychiatry, 2010; 15(8):844-849
Publisher: Nature Publishing Group
Issue Date: 2010
ISSN: 1359-4184
Statement of
A Schosser, D Gaysina, S Cohen-Woods, PC Chow, L Martucci, N Craddock, A Farmer, A Korszun, C Gunasinghe, J Gray, L Jones, F Tozzi, J Perry, P Muglia, MJ Owen, IW Craig, and P McGuffin
Abstract: The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD). The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX-DISC1 fusion protein. We explored the TSNAX-DISC1 gene region for an association with BD and MDD in a sample of 1984 patients (1469 MDD, 515 BD) and 1376 ethnically matched controls. Eight single nucleotide polymorphisms (SNPs) within the TSNAX-DISC1 region (rs766288, rs3738401, rs2492367, rs6675281, rs12133766, rs1000731, rs7546310 and rs821597) were investigated using the SNPlex Genotyping System. We found a significant allelic and genotypic association of the TSNAX-DISC1 gene region with BD, whereas a haplotypic association was found for both BD and MDD. Therefore, our results suggest an association between the TSNAX-DISC1 region and both forms of affective disorders, and support the hypothesis that a portion of the genotypic overlap between schizophrenia and affective disorders is attributable to this gene.
Keywords: bipolar disorder; depression; association; psychosis
Rights: © 2010 Macmillan Publishers Limited All rights reserved.
RMID: 0020124131
DOI: 10.1038/mp.2009.21
Appears in Collections:Psychiatry publications

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