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https://hdl.handle.net/2440/76229
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dc.contributor.author | Fisher, H. | - |
dc.contributor.author | Cohen-Woods, S. | - |
dc.contributor.author | Hosang, G. | - |
dc.contributor.author | Uher, R. | - |
dc.contributor.author | Powell-Smith, G. | - |
dc.contributor.author | Keers, R. | - |
dc.contributor.author | Tropeano, M. | - |
dc.contributor.author | Korszun, A. | - |
dc.contributor.author | Jones, L. | - |
dc.contributor.author | Jones, I. | - |
dc.contributor.author | Owen, M. | - |
dc.contributor.author | Craddock, N. | - |
dc.contributor.author | Craig, I. | - |
dc.contributor.author | Farmer, A. | - |
dc.contributor.author | McGuffin, P. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Journal of Affective Disorders, 2012; 136(1-2):189-193 | - |
dc.identifier.issn | 0165-0327 | - |
dc.identifier.issn | 1573-2517 | - |
dc.identifier.uri | http://hdl.handle.net/2440/76229 | - |
dc.description.abstract | <h4>Background</h4>An interaction between recent stressful life events (SLEs) and a serotonin transporter promoter polymorphism (5-HTTLPR) in depression has been inconsistently reported. Some of this variability may be due to a previous focus on sub-clinical depression, inclusion of individuals at the lower or upper ends of the age-span, or assumptions concerning the degree of dominance of the low expressing allele. Therefore, a large sample of patients with recurrent clinically diagnosed depression and controls screened for absence of depression was utilised to examine the moderating effect of each 5-HTTLPR genetic model on the association between SLEs and severe depressive episodes.<h4>Method</h4>A sample of 1236 recurrent unipolar depression cases and 598 age-matched, never psychiatrically ill controls completed the List of Threatening Experiences Questionnaire to assess the number of SLEs experienced in the 6 months prior to the most severe depressive episode (cases) or interview (controls). DNA extracted from blood or cheek swabs was genotyped for the short (s) and long (l) alleles of 5-HTTLPR.<h4>Results</h4>A greater number of SLEs were reported by cases than controls and this held across all genotypic groups. There was no main effect of 5-HTTLPR on depression and no evidence of interaction between total SLEs and any of the 5-HTTLPR genetic models. The results were the same for men and women.<h4>Limitations</h4>Utilisation of retrospective self-reported SLEs may have reduced the accuracy of the findings and the cross-sectional design prevents causal inference.<h4>Conclusions</h4>This study failed to find evidence of gene-environment interplay in recurrent clinical depression. | - |
dc.description.statementofresponsibility | Helen L. Fisher, Sarah Cohen-Woods, Georgina M. Hosang, Rudolf Uher, Georgia Powell-Smith, Robert Keers, Maria Tropeano, Ania Korszun, Lisa Jones, Ian Jones, Mike Owen, Nick Craddock, Ian W. Craig, Anne E. Farmer, Peter McGuffin | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science BV | - |
dc.rights | Copyright © 2011 Elsevier B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jad.2011.09.016 | - |
dc.subject | Stressful life events | - |
dc.subject | Unipolar depression | - |
dc.subject | Recurrent | - |
dc.subject | Gene–environment interaction | - |
dc.subject | 5-HTTLPR | - |
dc.title | Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jad.2011.09.016 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Cohen-Woods, S. [0000-0003-2199-6129] | - |
Appears in Collections: | Aurora harvest Psychiatry publications |
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