Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder|
|Citation:||Journal of Affective Disorders, 2010; 125(1-3):345-349|
|Publisher:||Elsevier Science BV|
|Georgina M. Hosang, Rudolf Uher, Robert Keers, Sarah Cohen-Woods, Ian Craig, Ania Korszun, Julia Perry, Federica Tozzi, Pierandrea Muglia, Peter McGuffin and Anne E. Farmer|
|Abstract:||<h4>Background</h4>Gene-environment interactions may contribute to the high heritability of bipolar affective disorder. The aim of the present study was to examine the interplay between the BDNF Val(66)Met polymorphism and stressful life events (SLEs) in bipolar disorder.<h4>Method</h4>A total of 1085 participants were recruited, including 487 bipolar I cases and 598 psychiatrically healthy controls. All participants completed the List of Threatening Life Events Questionnaire; bipolar subjects reported the events that occurred 6 months leading up to their worst manic episode and 6 months prior to their worst depressive episode, controls recorded events experienced 6 months before interview. The sample was genotyped for the BDNF Val(66)Met polymorphism (rs6265).<h4>Results</h4>Both Met carrier BDNF genotype and SLEs were significantly associated with the worst depressive episode of bipolar disorder. For the worst depressive episodes the effects of SLEs were also significantly moderated by BDNF genotype (gene x environment interaction).<h4>Limitations</h4>The use of a self report questionnaire to measure stressful life events may increase recall inaccuracies, therefore caution should be taken when interpreting these results.<h4>Discussion</h4>The findings of this study highlight the importance of the interplay between genes and the environment in bipolar disorder.|
Genetic Predisposition to Disease
Brain-Derived Neurotrophic Factor
Life Change Events
Genetic Carrier Screening
|Rights:||© 2010 Elsevier B.V. All rights reserved|
|Appears in Collections:||Aurora harvest 4|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.