Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/74717
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D-₃ levels in male mice |
Other Titles: | Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D-(3) levels in male mice |
Author: | Gorman, S. Scott, N. Tan, D. Weeden, C. Tuckey, R. Bisley, J. Grimbaldeston, M. Hart, P. |
Citation: | PLoS One, 2012; 7(9):1-12 |
Publisher: | Public Library of Science |
Issue Date: | 2012 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Makishima, M. |
Statement of Responsibility: | Shelley Gorman, Naomi M. Scott, Daryl H. W. Tan, Clare E. Weeden, Robert C. Tuckey, Jacqueline L. Bisley, Michele A. Grimbaldeston, Prue H. Hart |
Abstract: | Vitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator of the immunosuppression that occurs following UV radiation (UVR) exposure. Both UVR and vitamin D drive immune responses towards tolerance by ultimately increasing the suppressive activities of regulatory T cells. To examine a role for UVR-induced vitamin D, vitamin D₃-deficient mice were established by dietary vitamin D₃ restriction. In comparison to vitamin D₃-replete mice, vitamin D₃-deficient mice had significantly reduced serum levels of 25-hydroxyvitamin D₃ (25(OH)D₃, <20 nmol.L⁻¹) and 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃, <20 pmol.L⁻¹). Following either acute erythemal UVR, or chronic sub-erythemal UVR (8 exposures over 4 weeks) treatment, serum 25(OH)D₃ levels significantly increased in vitamin D₃-deficient female but not male mice. To determine if UVR-induced vitamin D was a mediator of UVR-induced systemic immunosuppression, responses were measured in mice that were able (female) or unable (male) to increase systemic levels of 25(OH)D₃ after UVR. Erythemal UVR (≥4 kJ/m²) suppressed contact hypersensitivity responses (T helper type-1 or -17), aspects of allergic airway disease (T helper type-2) and also the in vivo priming capacity of bone marrow-derived dendritic cells to a similar degree in female and male vitamin D₃-deficient mice. Thus, in male mice, UVR-induced 25(OH)D₃ is not essential for mediating the immunosuppressive effects of erythemal UVR. |
Keywords: | Dendritic Cells Bone Marrow Cells Skin Animals Mice, Inbred BALB C Mice Erythema Acute Disease Calcium Calcifediol Vitamin D Immunosuppressive Agents Bronchoalveolar Lavage Ultraviolet Rays Dose-Response Relationship, Radiation Immune Tolerance Female Male Immunosuppression Therapy |
Description: | Extent: 12p. |
Rights: | © 2012 Gorman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0046006 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0046006 |
Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_74717.pdf | Published version | 1.81 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.