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https://hdl.handle.net/2440/73884
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Type: | Journal article |
Title: | Status of clomiphene citrate and metformin for infertility in PCOS |
Author: | Misso, M. Teede, H. Hart, R. Wong, J. Rombauts, L. Melder, A. Norman, R. Costello, M. |
Citation: | Trends in Endocrinology and Metabolism, 2012; 23(10):533-543 |
Publisher: | Elsevier Science London |
Issue Date: | 2012 |
ISSN: | 1043-2760 1879-3061 |
Statement of Responsibility: | Marie L. Misso, Helena J. Teede, Roger Hart, Jennifer Wong, Luk Rombauts, Angela M. Melder, Robert J. Norman and Michael F. Costello |
Abstract: | Though widely used, there is uncertainty about the effectiveness and adverse effects of metformin and clomiphene citrate (CC) for infertility in polycystic ovary syndrome (PCOS). A systematic review (SR) of the best available evidence suggests that both CC and metformin are better than placebo for increasing ovulation and pregnancy rates, but CC is more effective than metformin for ovulation, pregnancy and live-birth rates, in PCOS patients with body mass index (BMI) >30. A combination of CC and metformin is superior to either metformin alone or CC alone, depending on the BMI and CC sensitivity of the patient. This SR provides key messages to guide clinicians and consumers on the use of these interventions in different subgroups of women with PCOS. |
Keywords: | Humans Polycystic Ovary Syndrome Infertility, Female Metformin Clomiphene Ovulation Induction Female |
Rights: | © 2012 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.tem.2012.07.001 |
Published version: | http://dx.doi.org/10.1016/j.tem.2012.07.001 |
Appears in Collections: | Aurora harvest 4 Medical Sciences publications |
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