Fabrication and properties of porous scaffold of zein/PCL biocomposite for bone tissue engineering

Abstract

The aim of this study was to fabricate porous scaffolds of zein/poly(-caprolactone) (PCL) biocomposite by solvent casting-particulate leaching method using sodium chloride particles as the porogen. Porous biocomposite scaffolds with porosity around 70% and well-interconnected network were obtained. The incorporation of zein into PCL led to the improvement of hydrophilicity as indicated by the results of water contact angle measurement. After immersion in phosphate buffered saline (PBS) in vitro for 28 days, it was observed that the degradation rate of the zein/PCL biocomposite scaffold was faster than the PCL scaffold and that the rate could be tailored by adjusting the amount of zein in the composite. The results demonstrate the potential of the zein/PCL biocomposite scaffolds to be used in tissue engineering strategies to regenerate bone defects. © 2012 Elsevier Ltd. All rights reserved.