Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/72463
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Type: Journal article
Title: Imaging periprosthetic osteolysis around total knee arthroplasties using a human cadaver model
Author: Solomon, L.
Stamenkov, R.
MacDonald, A.
Yaikwavong, N.
Neale, S.
Moss, M.
Howie, D.
Citation: Journal of Arthroplasty, 2012; 27(6):1069-1074
Publisher: Churchill Livingstone Inc Medical Publishers
Issue Date: 2012
ISSN: 0883-5403
1532-8406
Statement of
Responsibility: 
Lucian B. Solomon, Roumen B. Stamenkov, Andrew J. MacDonald, Nammon Yaikwavong, Susan D. Neale, Mary J. Moss and Donald W. Howie
Abstract: We examined the sensitivity and accuracy of measuring osteolysis around total knee arthroplasty (TKA) on radiographs, computed tomography (CT), and magnetic resonance imaging (MRI) in a cadaver model. Fifty-four simulated osteolytic defects ranging from 0.7 to 14 cm(3) were created in 6 cadaver knees implanted with either a cemented or an uncemented TKA. Three blinded investigators assessed the presence, location, and volume of defects on radiographs and CT and MRI scans with metal reduction protocols. Both CT and MRI had significantly higher sensitivities and specificities than did plain radiographs (P < .005). Overall, there was no difference in the accuracy of defect volume measurements between CT and MRI (P = .574). This study demonstrates the limitations of radiographs and the high sensitivity and specificity of both CT and MRI in assessing osteolysis around TKA.
Keywords: Humans; Osteolysis; Cadaver; Magnetic Resonance Imaging; Arthroplasty, Replacement, Knee; Sensitivity and Specificity; Knee Prosthesis; X-Rays; Four-Dimensional Computed Tomography
Rights: Crown Copyright © 2012 Published by Elsevier Inc. All rights reserved.
RMID: 0020119398
DOI: 10.1016/j.arth.2011.09.012
Appears in Collections:Orthopaedics and Trauma publications

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