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https://hdl.handle.net/2440/72112
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Type: | Journal article |
Title: | Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation |
Author: | Bosco, M. Mohanasundaram, D. Drogemuller, C. Lang, C. Zalewski, P. Coates, P. |
Citation: | The Review of Diabetic Studies, 2011; 7(4):263-274 |
Publisher: | Society for Biomedical Diabetes Research (SBDR) |
Issue Date: | 2011 |
ISSN: | 1613-6071 1614-0575 |
Statement of Responsibility: | Mariea D. Bosco, Daisy M. Mohanasundaram, Chris J. Drogemuller, Carol J. Lang, Peter D. Zalewski and P. Toby Coates |
Abstract: | The critical trace element zinc is essential for normal insulin production, and plays a central role in cellular protection against apoptosis and oxidative stress. The regulation of zinc within the pancreas and β-cells is controlled by the zinc transporter families ZnT and ZIP. Pancreatic islets display wide variability in the occurrence of these molecules. The zinc transporter, ZnT8 is an important target for autoimmunity in type 1 diabetes. Gene polymorphisms of this transporter confer sensitivity for immunosuppressive drugs used in islet transplantation. Understanding the biology of zinc transport within pancreatic islets will provide insight into the mechanisms of β-cell death, and may well reveal new pathways for improvement of diabetes therapy, including islet transplantation. This review discusses the possible roles of zinc in β-cell physiology with a special focus on islet transplantation. |
Keywords: | Type 1 Diabetes pancreatic islet beta-cell zinctransporter oxidative stress apoptosis ZnT ZIP insulinsecretion • transplantation |
Rights: | Copyright © by Lab & Life Press/SBDR |
DOI: | 10.1900/RDS.2010.7.263 |
Published version: | http://dx.doi.org/10.1900/rds.2010.7.263 |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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