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https://hdl.handle.net/2440/69384
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Type: | Journal article |
Title: | Muscle and adipose tissue biopsy in older adults with type 2 diabetes |
Author: | Wang, Y. Simar, D. Anderberg, K. Mavros, Y. Kay, S. Zhao, R. Baune, B. O'Sullivan, A. Singh, N. Fiatarone-Singh, M. |
Citation: | Journal of Diabetes Mellitus, 2011; 1(3):27-35 |
Publisher: | Scientific Research Publishing Inc |
Issue Date: | 2011 |
ISSN: | 2160-5831 2160-5858 |
Statement of Responsibility: | Yi Wang, David Simar, Kylie Anderberg, Yorgi Mavros, Shelley Kay, Renru Zhao, Bernhard T. Baune, Anthony O’Sullivan, Nalin Singh, Maria Fiatarone Singh |
Abstract: | We describe a method for obtaining skeletal muscle and subcutaneous adipose tissue in a single percutaneous needle biopsy procedure. Biopsies were performed in a double-blind randomized, sham-exercise controlled clinical trial of power training in 103 older adults with type 2 diabetes. In total 110 biopsies (73.3%) were performed in the first 50 participants at 3 time points. Muscle samples were obtained in 102/110 biopsies (92.7%); adipose samples were obtained in 72/110 biopsies (65.5%); both tissue types were obtained in 65/110 biopsies (59.1%). The average weight of muscle samples was 131±92 mg and the median weight of adipose samples was 51 mg (range 3 to 412 mg). No adverse effects of biopsies were reported other than mild transient pain or light-headedness. This is one of the first reports of both adipose and muscle tissue obtained during the same biopsy, and the first to describe in detail sampling technique, yield and safety. |
Keywords: | Biopsy Skeletal Muscle Subcutaneous Adipose Tissue Type 2 Diabetes |
Rights: | Copyright © 2011 SciRes. |
DOI: | 10.4236/jdm.2011.13005 |
Published version: | http://www.scirp.org/journal/PaperInformation.aspx?paperID=7083 |
Appears in Collections: | Aurora harvest Psychiatry publications |
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