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Type: Journal article
Title: Double dissociated effects of the functional TNF-α -308G/A polymorphism on processes of cognitive control
Other Titles: Double dissociated effects of the functional TNF-alpha -308G/A polymorphism on processes of cognitive control
Author: Beste, C.
Guentuerkuen, O.
Baune, B.
Domschke, K.
Falkenstein, M.
Konrad, C.
Citation: Neuropsychologia, 2011; 49(2):196-202
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2011
ISSN: 0028-3932
Statement of
Christian Beste, Onur Güntürkün, Bernhard T. Baune, Katharina Domschke, Michael Falkenstein, Carsten Konrad
Abstract: Neuroimmunological factors may modulate brain functions and are important to understand the molecular basis of cognition. The tumor necrosis factor alpha (TNF-α) is known to induce neurodegenerative changes in the basal ganglia, but the cognitive effects of these changes are not understood. Since the basal ganglia are neurobiologically heterogeneous, different cognitive functions mediated by basal ganglia-prefrontal loops (response inhibition and error processing) may not necessarily be uniformly affected. Response inhibition and error processing functions were examined using event-related potentials (ERPs) and subjects (N=71) were genotyped for the functional TNF-α -308G→A polymorphism. We show a double-dissociated effect of the functional TNF-α -308G→A polymorphism on response inhibition and error processing. While response inhibition functions were more effective in the AA/AG genotype group, error monitoring functions are adversely affected in this genotype group. In the GG genotype group, the pattern of results was vice versa. The results refine the view of the effects of TNF-α on cognitive functions.
Keywords: Response inhibition; Error processing; Event-related potentials (ERPs); TNF-alpha polymorphism; Basal ganglia
Rights: Copyright © 2010 Elsevier Ltd. All rights reserved.
RMID: 0020111604
DOI: 10.1016/j.neuropsychologia.2010.11.037
Appears in Collections:Psychiatry publications

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