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https://hdl.handle.net/2440/66953
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Type: | Journal article |
Title: | In vivo activity of benzoyl ester clerodane diterpenoid derivatives from Dodonaea polyandra |
Author: | Simpson, B. Claudie, D. Gerber, J. Pyke, S. Wang, J. McKinnon, R. Semple, S. |
Citation: | Journal of Natural Products, 2011; 74(4):650-657 |
Publisher: | Amer Chemical Soc |
Issue Date: | 2011 |
ISSN: | 0163-3864 1520-6025 |
Statement of Responsibility: | Bradley S. Simpson, David J. Claudie, Jacobus P. Gerber, Simon M. Pyke, Jiping Wang, Ross A. McKinnon and Susan J. Semple |
Abstract: | Four new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8α-(benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8α-(benzoyloxy)methyl-2α-hydroxycleroda-3,13(16),14-trien-18-oic acid (2), 15,16-epoxy-8α-(benzoyloxy)methyl-2-oxocleroda-3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2α-benzoyloxycleroda-3,13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 μmol/ear, respectively. Modest activity (~45% inhibition) was maintained at nanomole/ear doses. |
Keywords: | Ear Animals Mice Sapindaceae Plant Leaves Plant Stems Disease Models, Animal Edema Diterpenes, Clerodane Tetradecanoylphorbol Acetate Anti-Inflammatory Agents, Non-Steroidal Molecular Structure Australia |
Rights: | Copyright © 2011 The American Chemical Society and American Society of Pharmacognosy |
DOI: | 10.1021/np100701s |
Grant ID: | ARC |
Published version: | http://dx.doi.org/10.1021/np100701s |
Appears in Collections: | Aurora harvest 5 Chemistry and Physics publications |
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