Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/66090
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Emotion specific modulation of automatic amygdala responses by 5-HTTLPR genotype |
Author: | Dannlowski, U. Konrad, C. Kugel, H. Zwitserlood, P. Domschke, K. Schoning, S. Ohrmann, P. Bauer, J. Pyka, M. Hohoff, C. Zhang, W. Baune, B. Heindel, W. Arolt, V. Suslow, T. |
Citation: | NeuroImage, 2010; 53(5):893-898 |
Publisher: | Academic Press Inc Elsevier Science |
Issue Date: | 2010 |
ISSN: | 1053-8119 1095-9572 |
Statement of Responsibility: | Udo Dannlowski, Carsten Konrad, Harald Kugel, Pienie Zwitserlood, Katharina Domschke, Sonja Schöning, Patricia Ohrmann, Jochen Bauer, Martin Pyka, Christa Hohoff, Weiqi Zhang, Bernhard T. Baune, Walter Heindel, Volker Arolt, Thomas Suslow |
Abstract: | A functional polymorphism in the serotonin transporter gene (5-HTTLPR) has been reported to modulate amygdala responsiveness to negative environmental cues. However, it remains unclear whether 5-HTTLPR modulates amygdala responses specifically to negative stimuli or rather to emotionally salient stimuli in general. In 44 healthy subjects, amygdala responses to subliminally presented happy and sad facial expressions were assessed by means of fMRI at 3 Tesla. All subjects were genotyped for 5-HTTLPR and the recently discovered 5-HTT rs25531. We observed a robust emotion by genotype group interaction in the right amygdala. Risk allele carriers (S or L(G)) showed similar amygdala responses to happy faces compared to homozygous L(A)L(A) carriers but increased amygdala responses to sad faces. The right amygdala was the only anatomical region across the whole brain demonstrating this interaction at a reasonable threshold. It appears that whereas 5-HTT gene variation modulates automatic amygdala responsiveness to sad faces, no such association was found for happy faces. We conclude that 5-HTTLPR genotype predominantly impacts the central processing predominantly of negative environmental cues but not of emotionally salient stimuli in general. |
Keywords: | Serotonin 5-HTTLPR Amygdala Genetics fMRI Depression |
Rights: | © 2009 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.neuroimage.2009.11.073 |
Published version: | http://dx.doi.org/10.1016/j.neuroimage.2009.11.073 |
Appears in Collections: | Aurora harvest Psychiatry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.