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|Title:||Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression|
|Citation:||European Neuropsychopharmacology, 2010; 20(5):301-309|
|Publisher:||Elsevier Science BV|
|Katharina Domschke, Udo Dannlowski, Christa Hohoff, Patricia Ohrmann, Jochen Bauer, Harald Kugel, Peter Zwanzger, Walter Heindel, Jürgen Deckert, Volker Arolt, Thomas Suslow, Bernhard T. Baune|
|Abstract:||Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of "anxious depression". Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. Additionally, NPY gene impact on amygdala activation during facial emotion processing was analyzed in a subsample of 35 depressed patients. Particularly in anxious depression, the less active NPY rs16147 -399C allele conferred slow response after 2weeks and failure to achieve remission after four weeks of treatment. The rs16147 C allele was further associated with stronger bilateral amygdala activation in response to threatening faces in an allele-dose fashion. The present results point towards a possible influence of functional NPY gene variation on antidepressant treatment response in anxious depression, potentially conveyed by altered emotional processing.|
|Keywords:||Pharmacogenetics; Imaging genetics; Depression; Anxiety; NPY|
|Rights:||© 2009 Elsevier B.V. and ECNP. All rights reserved.|
|Appears in Collections:||Psychiatry publications|
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