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https://hdl.handle.net/2440/66046
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Type: | Journal article |
Title: | Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression |
Author: | Domschke, K. Dannlowski, U. Hohoff, C. Ohrmann, P. Bauer, J. Kugel, H. Zwanzger, P. Heindel, W. Deckert, J. Arolt, V. Suslow, T. Baune, B. |
Citation: | European Neuropsychopharmacology, 2010; 20(5):301-309 |
Publisher: | Elsevier Science BV |
Issue Date: | 2010 |
ISSN: | 0924-977X 1873-7862 |
Statement of Responsibility: | Katharina Domschke, Udo Dannlowski, Christa Hohoff, Patricia Ohrmann, Jochen Bauer, Harald Kugel, Peter Zwanzger, Walter Heindel, Jürgen Deckert, Volker Arolt, Thomas Suslow, Bernhard T. Baune |
Abstract: | Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of "anxious depression". Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. Additionally, NPY gene impact on amygdala activation during facial emotion processing was analyzed in a subsample of 35 depressed patients. Particularly in anxious depression, the less active NPY rs16147 -399C allele conferred slow response after 2weeks and failure to achieve remission after four weeks of treatment. The rs16147 C allele was further associated with stronger bilateral amygdala activation in response to threatening faces in an allele-dose fashion. The present results point towards a possible influence of functional NPY gene variation on antidepressant treatment response in anxious depression, potentially conveyed by altered emotional processing. |
Keywords: | Pharmacogenetics Imaging genetics Depression Anxiety NPY |
Rights: | © 2009 Elsevier B.V. and ECNP. All rights reserved. |
DOI: | 10.1016/j.euroneuro.2009.09.006 |
Published version: | http://dx.doi.org/10.1016/j.euroneuro.2009.09.006 |
Appears in Collections: | Aurora harvest 5 Psychiatry publications |
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