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Type: Journal article
Title: Association between genetic variants of the metabotropic glutamate receptor 3 (GRM3) and cognitive set shifting in healthy individuals
Author: Baune, B.
Suslow, T.
Beste, C.
Birosova, E.
Domschke, K.
Sehlmeyer, C.
Konrad, C.
Citation: Genes, Brain and Behavior, 2010; 9(5):459-466
Publisher: Blackwell Munksgaard
Issue Date: 2010
ISSN: 1601-1848
Statement of
B. T. Baune, T. Suslow, C. Beśte, E. Birosova, K. Domschke, C. Sehlmeyer and C. Konrad
Abstract: Set-shifting and maintenance are complex cognitive processes, which are often impaired in schizophrenia. The genetic basis of these processes is poorly understood. We aimed to investigate the association between genetic variants of the metabotropic glutamate receptor 3 (GRM3) and cognitive set-shifting in healthy individuals. The relationship between 14 selected single nucleotide polymorphisms (SNPs) of the GRM3 gene and cognitive set-shifting as measured by perseverative errors using the modified card sorting test (MCST) was analysed in a sample of N = 98 young healthy individuals (mean age in years: 22.7 +/- 0.19). Results show that SNP rs17676277 is related to the performance on the MCST. Subjects with the TT genotype showed significantly less perseverative errors as compared with the AA (P = 0.025) and AT (P = 0.0005) and combined AA/AT genotypes (P = 0.0005). Haplotype analyses suggest the involvement of various SNPs of the GRM3 gene in perseverative error processing in a dominant model of inheritance. The findings strongly suggest that the genetic variation (rs17676277 and three haplotypes) in the metabotropic GRM3 is related to cognitive set-shifting in healthy individuals independent of working memory. However, because of a relatively small sample size for a genetic association study, the present results are tentative and require replication.
Keywords: Healthy individuals; metabotropic glutamate receptor 3; perseverative errors; schizophrenia; working memory
Rights: © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd/International Behavioural and Neural Genetics Society
RMID: 0020111299
DOI: 10.1111/j.1601-183X.2010.00573.x
Appears in Collections:Psychiatry publications

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