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https://hdl.handle.net/2440/65864
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dc.contributor.author | Baune, B. | - |
dc.contributor.author | Hohoff, C. | - |
dc.contributor.author | Mortensen, L. | - |
dc.contributor.author | Deckert, J. | - |
dc.contributor.author | Arolt, V. | - |
dc.contributor.author | Domschke, K. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Depression and Anxiety, 2008; 25(11):920-925 | - |
dc.identifier.issn | 1091-4269 | - |
dc.identifier.issn | 1520-6394 | - |
dc.identifier.uri | http://hdl.handle.net/2440/65864 | - |
dc.description.abstract | Earlier studies yielded inconsistent results on the association between variation in the serotonin transporter (5-HTT) gene and depression, with evidence for a differential effect of the 5-HTTLPR on melancholic versus atypical depression. To further delineate the impact of 5-HTT gene variation on psychopathology in depression, in this analysis the influence of the 5-HTTLPR and the functionally closely related 5-HTT rs25531 was investigated in 340 Caucasian patients with a major depressive episode (DSM-IV) with particular attention to the subtype of depression (melancholic depression versus atypical depression) applying logistic regression models adjusted for age and gender. The homozygous, more active 5-HTTLPR LL genotype was significantly associated with melancholic depression (odds ratio, OR, 1.7; 95% confidence interval, CI, 1.1-2.6; P=0.04), with the effect originating in the female subgroup of patients (OR 1.9; 95%CI 1.0-3.4; P=0.05). Also, the more active 5-HTTLPR/5-HTT rs25531 haplotype L(A)L(A) conveyed a significant risk for melancholic depression (OR 2.0; 95%CI 1.3-3.1; P=0.001), again only in the female subsample of patients (OR 2.1; 95%CI 1.1-4.1; P=0.02). The present results provide further support for an association of genetic variation increasing serotonin transporter activity with the melancholic subtype of depression as well as evidence for a potential female-specific mechanism underlying this effect. | - |
dc.description.statementofresponsibility | Bernhard T. Baune, Christa Hohoff, Lena S. Mortensen, Jürgen Deckert, Volker Arolt and Katharina Domschke | - |
dc.language.iso | en | - |
dc.publisher | Wiley-Liss | - |
dc.rights | © 2007 Wiley-Liss, Inc. | - |
dc.source.uri | http://dx.doi.org/10.1002/da.20433 | - |
dc.subject | major depressive episode | - |
dc.subject | melancholic depression | - |
dc.subject | serotonin transporter | - |
dc.subject | gender effect | - |
dc.title | Serotonin transporter polymorphism (5-HTTLPR) association with melancholic depression: a female specific effect? | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/da.20433 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Baune, B. [0000-0001-6548-426X] | - |
Appears in Collections: | Aurora harvest 5 Psychiatry publications |
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