Adelaide Research & Scholarship
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https://hdl.handle.net/2440/65744
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| Type: | Journal article |
| Title: | HTR2A gene variation is involved in antidepressant treatment response |
| Author: | Lucae, S. Ising, M. Horstmann, S. Baune, B. Arolt, V. Muller-Myhsok, B. Holsboer, F. Domschke, K. |
| Citation: | European Neuropsychopharmacology, 2010; 20(1):65-68 |
| Publisher: | Elsevier Science BV |
| Issue Date: | 2010 |
| ISSN: | 0924-977X 1873-7862 |
| Statement of Responsibility: | Susanne Lucae, Marcus Ising, Sonja Horstmann, Bernhard T. Baune, Volker Arolt, Bertram Müller-Myhsok, Florian Holsboer, Katharina Domschke |
| Abstract: | Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STARD sample. |
| Keywords: | HTR2A Pharmacogenetics SNP Treatment response Major Depression Association study |
| Rights: | © 2009 Elsevier B.V. and ECNP All rights reserved. |
| DOI: | 10.1016/j.euroneuro.2009.08.006 |
| Published version: | http://dx.doi.org/10.1016/j.euroneuro.2009.08.006 |
| Appears in Collections: | Aurora harvest Psychiatry publications |
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