Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/65741
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dc.contributor.authorBaune, B.en
dc.contributor.authorDannlowski, U.en
dc.contributor.authorDomschke, K.en
dc.contributor.authorJanssen, D.en
dc.contributor.authorJordan, M.en
dc.contributor.authorOhrmann, P.en
dc.contributor.authorBauer, J.en
dc.contributor.authorBiros, E.en
dc.contributor.authorArolt, V.en
dc.contributor.authorKugel, H.en
dc.contributor.authorBaxter, A.en
dc.contributor.authorSuslow, T.en
dc.date.issued2010en
dc.identifier.citationBiological Psychiatry, 2010; 67(6):543-549en
dc.identifier.issn0006-3223en
dc.identifier.issn1873-2402en
dc.identifier.urihttp://hdl.handle.net/2440/65741-
dc.description.abstractBackground: Accumulating evidence suggests the involvement of inflammatory processes and cytokines in particular in the pathophysiology of major depression (MDD) and resistance to antidepressant treatment. Furthermore, amygdala and anterior cingulate cortex (ACC) responsiveness to emotional stimuli has been suggested as a predictor of treatment response. This study investigated the association between genetic variants of the interleukin 1 beta (IL1B) gene and amygdala and ACC responsiveness to emotional stimuli and response to antidepressant treatment. Methods: In this analysis, 256 Caucasian patients with MDD (145 women, 111 men) were genotyped for variants rs16944, rs1143643, and rs1143634 in the IL1B gene (2q14). Response to antidepressant treatment over 6 weeks was defined as remission (≤ 7 on the Hamilton Rating Scale for Depression–21-question) and response (>50% decrease on Hamilton Rating Scale for Depression–21-question). Brain activity under visual presentation of emotional faces was assessed in a subsample of 32 depressed patients by means of functional magnetic resonance imaging at 3 T. Results: Pharmacogenetic analyses show significant associations of the GG genotypes of single nucleotide polymorphisms (SNPs) rs16944 (odds ratio = 1.74; 95% confidence interval 1.2–4.3) and rs1143643 (odds ratio = 3.1; 95% confidence interval 1.3–7.8) (compared with the AA genotype) with nonremission after 6 weeks. The imaging analyses show that the number of G-alleles in both SNPs (rs16944 and rs1143643) was associated with reduced responsiveness of the amygdala and ACC to emotional stimulation. Conclusions: The present study suggests a negative effect of the IL1B gene on pharmacological response and amygdala and ACC function involving the same genotypes of two SNPs (rs16944, rs116343), which taken together increase the risk of nonremission over 6 weeks of antidepressant treatment in MDD.en
dc.description.statementofresponsibilityBernhard T. Baune, Udo Dannlowski, Katharina Domschke, Debbie G.A. Janssen, Margaret A. Jordan, Patricia Ohrmann, Jochen Bauer, Erik Biros, Volker Arolt, Harald Kugel, Alan G. Baxter, and Thomas Suslowen
dc.language.isoenen
dc.publisherElsevier Science Incen
dc.rights© 2010 Society of Biological Psychiatryen
dc.subjectAmygdala and cingulate; antidepressant treatment response; depression; inflammation; interleukin 1 beta; pharmacogeneticsen
dc.titleThe Interleukin 1 Beta (IL1B) Gene Is Associated with Failure to Achieve Remission and Impaired Emotion Processing in Major Depressionen
dc.typeJournal articleen
dc.identifier.rmid0020111322en
dc.identifier.doi10.1016/j.biopsych.2009.11.004en
dc.identifier.pubid28368-
pubs.library.collectionPsychiatry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidBaune, B. [0000-0001-6548-426X]en
Appears in Collections:Psychiatry publications

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