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Type: Journal article
Title: Association of the COMT val158met Variant with Antidepressant Treatment Response in Major Depression
Author: Baune, B.
Hohoff, C.
Berger, K.
Neumann, A.
Mortensen, S.
Roehrs, T.
Deckert, J.
Arolt, V.
Domschke, K.
Citation: Neuropsychopharmacology, 2008; 33(4):924-932
Publisher: Elsevier Science Inc
Issue Date: 2008
ISSN: 0893-133X
Statement of
Bernhard T Baune, Christa Hohoff, Klaus Berger, Anna Neumann, Sünke Mortensen, Tilmann Roehrs, Jürgen Deckert, Volker Arolt and Katharina Domschke
Abstract: In several previous biochemical, pharmacological, and genetic studies, the catechol-O-methyltransferase (COMT) has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of affective disorders. In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks. The COMT 158val/val genotype conferred a significant risk of worse response after 4–6 weeks of antidepressant treatment in patients with major depression (week 4: p=0.003; week 5: p<0.0001; week 6: p<0.0001) after Bonferroni correction for multiple comparisons. The present results strongly point toward a negative influence of the higher activity COMT 158val/val genotype on antidepressant treatment response during the first 6 weeks of pharmacological treatment in major depression, possibly conferred by consecutively decreased dopamine availability. This finding suggests a potentially beneficial effect of an antidepressive add-on therapy with substances increasing dopamine availability individually tailored according to COMT val158met genotype.
Keywords: major depression; catechol-O-methyltransferase; COMT val158met; polymorphism; antidepressants; treatment response
Rights: © 2008 Nature Publishing Group. All rights reserved.
RMID: 0020111598
DOI: 10.1038/sj.npp.1301462
Appears in Collections:Psychiatry publications

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