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https://hdl.handle.net/2440/63821
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Type: | Journal article |
Title: | Cutting edge: Basophils are transiently recruited into the draining lymph nodes during Helminth infection via IL-3, but infection-induced Th2 immunity can develop without Basophil lymph node recruitment or IL-3 |
Author: | Kim, S. Prout, M. Ramshaw, H. Lopez, A. LeGros, G. Min, B. |
Citation: | Journal of Immunology, 2010; 184(3):1143-1147 |
Publisher: | Amer Assoc Immunologists |
Issue Date: | 2010 |
ISSN: | 0022-1767 1550-6606 |
Statement of Responsibility: | Sohee Kim, Melanie Prout, Hayley Ramshaw, Angel F. Lopez, Graham LeGros and Booki Min |
Abstract: | Basophils are recognized as immune modulators through their ability to produce IL-4, a key cytokine required for Th2 immunity. It has also recently been reported that basophils are transiently recruited into the draining lymph node (LN) after allergen immunization and that the recruited basophils promote the differentiation of naive CD4 T cells into Th2 effector cells. Using IL-3−/− and IL-3Rβ−/− mice, we report in this study that the IL-3/IL-3R system is absolutely required to recruit circulating basophils into the draining LN following helminth infection. Unexpectedly, the absence of IL-3 or of basophil LN recruitment played little role in helminth-induced Th2 immune responses. Moreover, basophil depletion in infected mice did not diminish the development of IL-4–producing CD4 T cells. Our results reveal a previously unknown role of IL-3 in recruiting basophils to the LN and demonstrate that basophils are not necessarily associated with the development of Th2 immunity during parasite infection. |
Keywords: | Lymph Nodes Basophils Th2 Cells Animals Mice, Inbred BALB C Mice, Knockout Mice Nippostrongylus Strongylida Infections Interleukin-3 Receptors, Interleukin-3 Cell Movement Gene Knock-In Techniques |
Rights: | Copyright © 2010 by The American Association of Immunologists, Inc. |
DOI: | 10.4049/jimmunol.0902447 |
Published version: | http://dx.doi.org/10.4049/jimmunol.0902447 |
Appears in Collections: | Aurora harvest Medicine publications |
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