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https://hdl.handle.net/2440/6316
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Type: | Journal article |
Title: | A double-blind, multicentre study to assess the tolerability and efficacy of paroxetine compared with amitriptyline in the treatment of depressed patients in Australian general practice |
Author: | Freed, E. Goldney, R. Lambert, T. Tiller, J. Johnston, R. |
Citation: | Australian and New Zealand Journal of Psychiatry, 1999; 33(3):416-421 |
Publisher: | SAGE Publications |
Issue Date: | 1999 |
ISSN: | 0004-8674 1440-1614 |
Statement of Responsibility: | Edgar Freed, Robert Goldney, Timothy Lambert, John Tiller, Robyn Johnston |
Abstract: | <h4>Objective</h4>This study compared the tolerability and efficacy of paroxetine and amitriptyline in the treatment of depression in general practice.<h4>Methods</h4>In this double-blind, multicentre study conducted in the general practice, patients with depression (Montgomery Asberg Depression Rating Scale [MADRS] score > or = 20) who were regarded as requiring antidepressant therapy were randomly assigned to receive paroxetine (20 mg, n = 184) or amitriptyline (50-100 mg, n = 191) once daily for 9 weeks.<h4>Results</h4>More patients completed treatment with paroxetine than with amitriptyline (71.1% vs 56.1%, p = 0.009). Depression rating scores (MADRS and Clinical Global Impression [CGI]) were improved with both agents, but at week 9, paroxetine achieved more favourable scores compared with amitriptyline on MADRS (p=0.019), CGI severity of depression (p=0.044), and CGI efficacy index (p = 0.038).<h4>Conclusions</h4>Depressed patients treated in general practice respond more quickly and are more likely to complete the treatment regimen with paroxetine than with amitriptyline. |
Keywords: | Humans Paroxetine Amitriptyline Antidepressive Agents, Second-Generation Antidepressive Agents, Tricyclic Treatment Outcome Drug Administration Schedule Chi-Square Distribution Double-Blind Method Depressive Disorder Time Factors Adult Aged Aged, 80 and over Middle Aged Primary Health Care Australia Female Male Selective Serotonin Reuptake Inhibitors |
DOI: | 10.1046/j.1440-1614.1999.00565.x |
Published version: | http://dx.doi.org/10.1046/j.1440-1614.1999.00565.x |
Appears in Collections: | Aurora harvest Psychiatry publications |
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