Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/62806
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Full metadata record
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dc.contributor.author | Deane, A. | - |
dc.contributor.author | Chapman, M. | - |
dc.contributor.author | Horowitz, M. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Critical Care (UK), 2010; 14(5):1-3 | - |
dc.identifier.issn | 1466-609X | - |
dc.identifier.issn | 1466-609X | - |
dc.identifier.uri | http://hdl.handle.net/2440/62806 | - |
dc.description | Commentary | - |
dc.description.abstract | Glucagon-like peptide-1 (GLP-1), a principal mediator of the postprandial insulinotropic response in health, has a half-life of minutes. The saliva of the Gila monster contains exendin-4, a structural analogue of human GLP-1, but with a much longer half-life. A synthetic preparation of exendin-4, exenatide, is suitable for human use and effectively lowers glucose in ambulant type 2 diabetic patients. When compared with insulin, exenatide therapy is associated with a reduction in hypoglycaemic episodes and postprandial glycaemic excursions in this group. Accordingly, GLP-1 analogues are appealing therapies for hyperglycaemia in the critically ill patient and warrant further study. | - |
dc.description.statementofresponsibility | Adam M Deane, Marianne J Chapman and Michael Horowitz | - |
dc.language.iso | en | - |
dc.publisher | Current Science Ltd | - |
dc.rights | © 2010 BioMed Central Ltd | - |
dc.source.uri | http://dx.doi.org/10.1186/cc9281 | - |
dc.subject | Venoms | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Lizards | - |
dc.subject | Reptilian Proteins | - |
dc.subject | Glucagon-Like Peptide 1 | - |
dc.title | The therapeutic potential of a venomous lizard: the use of glucagon-like peptide-1 analogues in the critically ill | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1186/cc9281 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Deane, A. [0000-0002-7620-5577] | - |
dc.identifier.orcid | Chapman, M. [0000-0003-0710-3283] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest |
Files in This Item:
File | Description | Size | Format | |
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hdl_62806.pdf | Published version | 128.51 kB | Adobe PDF | View/Open |
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