Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Long-term mechanical consequences of permanent right ventricular pacing: Effect of pacing site|
|Citation:||Journal of Cardiovascular Electrophysiology, 2010; 21(10):1120-1126|
|Publisher:||Futura Publ Co|
|Darryl P. Leong, Anne-Marie Mitchell, Ingrid Salna, Anthony G. Brooks, Gautam Sharma, Han S. Lim, Muayad Alasady, Malcolm Barlow, James Leitch, Prashanthan Sanders and Glenn D. Young|
|Abstract:||INTRODUCTION: Long-term right ventricular apical (RVA) pacing has been associated with adverse effects on left ventricular systolic function; however, the comparative effects of right ventricular outflow tract (RVOT) pacing are unknown. Our aim was therefore to examine the long-term effects of septal RVOT versus RVA pacing on left ventricular and atrial structure and function. METHODS: Fifty-eight patients who were prospectively randomized to long-term pacing either from the right ventricular apex or RVOT septum were studied echocardiographically. Left ventricular (LV) and atrial (LA) volumes were measured. LV 2D strain and tissue velocity images were analyzed to measure 18-segment time-to-peak longitudinal systolic strain and 12-segment time-to-peak systolic tissue velocity. Intra-LV synchrony was assessed by their respective standard deviations. Interventricular mechanical delay was measured as the difference in time-to-onset of systolic flow in the RVOT and LV outflow tract. Septal A’ was measured using tissue velocity images. RESULTS: Following 29 ± 10 months pacing, there was a significant difference in LV ejection fraction (P < 0.001), LV end-systolic volume (P = 0.007), and LA volume (P = 0.02) favoring the RVOT-paced group over the RVA-paced patients. RVA-pacing was associated with greater interventricular mechanical dyssynchrony and intra-LV dyssynchrony than RVOT-pacing. Septal A’ was adversely affected by intra-LV dyssynchrony (P < 0.05). CONCLUSIONS: Long-term RVOT-pacing was associated with superior indices of LV structure and function compared with RVA-pacing, and was associated with less adverse LA remodeling. If pacing cannot be avoided, the RVOT septum may be the preferred site for right ventricular pacing.|
|Keywords:||Doppler echocardiography; LV function; pacemaker; ventricular dyssynchrony tissue|
|Rights:||© 2010 Wiley Periodicals|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.