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https://hdl.handle.net/2440/5630
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Type: | Journal article |
Title: | Effects of epidermal growth factor administration on repair of acetic acid-induced colonic ulcerations in rats |
Author: | Ribbons, K. Howarth, G. Ford, W. George-Nascimento, C. Bourne, A. Read, L. |
Citation: | Growth Factors, 1997; 14(2-3):89-101 |
Publisher: | HARWOOD ACAD PUBL GMBH |
Issue Date: | 1997 |
ISSN: | 0897-7194 1029-2292 |
Statement of Responsibility: | Karen A. Ribbons, Gordon S. Howarth, W. D. Andrew Ford, Carlos George-Nascimento, Anthony J. Bourne, Leanna C. Read |
Abstract: | The effect of subcutaneous and luminal epidermal growth factor (EGF) administration on acetic acid-induced colonic ulceration was determined in adult rats. Application of acetic acid to the distal colonic lumen caused epithelial denudation, mucosal ulceration and inflammation in the exposed segment. Re-epithelialization was detectable 5 to 7 days later, with near-complete resolution of the lesion by 14 days post-injury. Luminal EGF (1.6 mg/kg bw/day) or subcutaneous EGF (200 micromilligrams/kg bw/day), administered for 4 or 6 days from the time of ulceration failed to enhance re-epithelialization of the acid-exposed segment. However, mucosal and submucosal thickening was attenuated 20-40% by subcutaneous EGF, reflecting a reduction in edema. Luminal EGF had a similar but less substantial effect in the submucosa, but was more effective at attenuating muscularis thickening adjacent to the lesion. In conclusion, administration of exogenous EGF for up to 6 days failed to enhance re-epithelialization of acetic acid-induced colonic ulcerations but did attenuate the associated edematous response. |
Keywords: | Intestinal Mucosa Colon Epithelium Animals Rats Rats, Sprague-Dawley Colonic Diseases Ulcer Edema Acetic Acid Epidermal Growth Factor Proliferating Cell Nuclear Antigen Histocytochemistry Cell Division Male |
DOI: | 10.3109/08977199709021513 |
Published version: | http://dx.doi.org/10.3109/08977199709021513 |
Appears in Collections: | Aurora harvest Pathology publications |
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