Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/5339
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Distribution of a putative endothelial barrier antigen in the ocular and orbital tissues of the rat |
Author: | Lawrenson, J. Ghabriel, M. Reid, A. Gajree, T. Allt, G. |
Citation: | British Journal of Ophthalmology, 1995; 79(5):462-466 |
Publisher: | BMJ Publishing Group |
Issue Date: | 1995 |
ISSN: | 0007-1161 1468-2079 |
Statement of Responsibility: | J G Lawrenson, Mounir N Ghabriel, A R Reid, T N Gajree, and G Allt |
Abstract: | BACKGROUND--A rat endothelial barrier antigen (EBA) recognised by a monoclonal antibody has been shown to be expressed strongly by endothelial cells of brain capillaries possessing a blood-brain barrier and only weakly expressed by fenestrated brain vessels. METHODS--In this study immunocytochemical methods for light and electron microscopy were used to study EBA distribution in the eye and orbital tissues of the rat. RESULTS--Blood-ocular barrier vessels in the optic nerve, retina, iris, and some vessels in th choroid and ciliary body were immunopositive for EBA. By pre-embedding immunocytochemistry for electron microscopy the antigen was observed on the luminal endothelial cell surface. CONCLUSION--Surprisingly, some non-barrier vessels in the ciliary body and choroid expressed EBA suggesting that it may play a broader role in endothelial properties than previously recognised. The functional significance of EBA remains to be elucidated. |
Keywords: | Eye Orbit Blood-Brain Barrier Optic Nerve Retina Choroid Ciliary Body Iris Animals Rats Rats, Sprague-Dawley Antigens, Surface Microscopy, Immunoelectron Immunohistochemistry Male |
DOI: | 10.1136/bjo.79.5.462 |
Published version: | http://dx.doi.org/10.1136/bjo.79.5.462 |
Appears in Collections: | Anatomical Sciences publications Aurora harvest 5 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.