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Type: Journal article
Title: Biodegradable injectable polyurethanes: Synthesis and evaluation for orthopaedic applications
Author: Adhikari, R.
Gunatillake, P.
Griffiths, I.
Tatai, L.
Wickramaratna, M.
Houshyar, S.
Moore, T.
Mayadunne, R.
Field, J.
Mc Gee, M.
Carbone, T.
Citation: Biomaterials, 2008; 29(28):3762-3770
Publisher: Elsevier Sci Ltd
Issue Date: 2008
ISSN: 0142-9612
Statement of
Raju Adhikari, Pathiraja A. Gunatillake, Ian Griffiths, Lisa Tatai, Malsha Wickramaratna, Shadi Houshyar, Tim Moore, Roshan T.M. Mayadunne, John Field, Margaret McGee and Tania Carbone
Abstract: Biodegradable polyurethanes offer advantages in the design of injectable or preformed scaffolds for tissue engineering and other medical implant applications. We have developed two-part injectable prepolymer systems (prepolymer A and B) consisting of lactic acid and glycolic acid based polyester star polyols, pentaerythritol (PE) and ethyl lysine diisocyanate (ELDI). This study reports on the formulation and properties of a series of cross linked polyurethanes specifically developed for orthopaedic applications. Prepolymer A was based on PE and ELDI. Polyester polyols (prepolymer B) were based on PE and dl-lactic acid (PEDLLA) or PE and glycolic acid (PEGA) with molecular weights 456 and 453, respectively. Several cross linked porous and non-porous polyurethanes were prepared by mixing and curing prepolymers A and B and their mechanical and thermal properties, in vitro (PBS/37 degrees C/pH 7.4) and in vivo (sheep bi-lateral) degradation evaluated. The effect of incorporating beta-tricalcium phosphate (beta-TCP, 5 microns, 10 wt.%) was also investigated. The cured polymers exhibited high compressive strength (100-190 MPa) and modulus (1600-2300 MPa). beta-TCP improved mechanical properties in PEDLLA based polyurethanes and retarded the onset of in vitro and in vivo degradation. Sheep study results demonstrated that the polymers in both injectable and precured forms did not cause any surgical difficulties or any adverse tissue response. Evidence of new bone growth and the gradual degradation of the polymers were observed with increased implant time up to 6 months.
Keywords: Animals
Lactic Acid
Biocompatible Materials
Tissue Engineering
Materials Testing
Implants, Experimental
Surface Properties
Description: Copyright © 2008 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.biomaterials.2008.06.021
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Orthopaedics and Trauma publications

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