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Type: Journal article
Title: The effect of intraduodenal glucose on muscle sympathetic nerve activity in healthy young and older subjects
Author: Van Orshoven, N.
Van Schelven, L.
Akkermans, L.
Jansen, P.
Horowitz, M.
Feinle-Bisset, C.
Van Huffelen, A.
Oey, P.
Citation: Clinical Autonomic Research, 2008; 18(1):28-35
Publisher: Dr Dietrich Steinkopf Verlag
Issue Date: 2008
ISSN: 0959-9851
Statement of
Narender P. van Orshoven, Leonard J. van Schelven, Louis M. A. Akkermans, Paul A. F. Jansen, Michael Horowitz, Christine Feinle-Bisset, Alexander C. van Huffelen and P. Liam Oey
Abstract: Objective The cardiovascular response to a meal is modulated by gastric distension and the interaction of nutrients, particularly carbohydrate, within the small intestine. We tested the hypothesis that the depressor effect of small intestinal glucose is greater in older than in young subjects, because the reflex increase in muscle sympathetic nerve activity (MSNA) is blunted by age. Methods The effects of intraduodenal glucose infusion (IDGI) on blood pressure, heart rate and MSNA were evaluated in eight healthy young subjects (4 women; mean age ± SEM: 28.8 ± 3.4 years), eight healthy elderly (4 women; 75.3 ± 1.6 years) and in two patients with symptomatic postprandial hypotension (PPH), one young (21 years), and one old (90 years). Results In both young and elderly healthy subjects, IDGI decreased blood pressure (P < 0.05), but the fall in systolic blood pressure was greater in the older subjects (−17.0 ± 4.1 vs. −6.5 ± 1.6 mmHg, P < 0.03). MSNA increased similarly, after infusion in both young (9.0 ± 3.4 bursts/min) and elderly (7.8 ± 1.0 bursts/min) subjects. Baroreflex sensitivity for number of sympathetic bursts was attenuated in the elderly (P < 0.03). The increase in burst area in the young patient with PPH was attenuated (18 vs. 63% in the healthy young group). Interpretation The fall in BP induced by IDGI was greater in healthy elderly compared to healthy young subjects. The reason for this is unclear, as they have similar increases in MSNA.
Keywords: aging; baroreceptors; blood pressure; heart rate; autonomic nervous system; postprandial hypotension; sympathetic activity; MSNA
Description: The original publication can be found at
RMID: 0020080260
DOI: 10.1007/s10286-008-0452-5
Appears in Collections:Medicine publications

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