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https://hdl.handle.net/2440/4850
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Type: | Journal article |
Title: | Bioactive dahlein peptides from the skin secretions of the Australian aquatic frog Litoria dahlii: sequence determination by electrospray mass spectrometry |
Author: | Wegener, K. Brinkworth, C. Bowie, J. Wallace, J. Tyler, M. |
Citation: | Rapid Communications in Mass Spectrometry, 2001; 15(18):1726-1734 |
Publisher: | John Wiley & Sons Ltd |
Issue Date: | 2001 |
ISSN: | 0951-4198 1097-0231 |
Statement of Responsibility: | Kate L. Wegener, Craig S. Brinkworth, John H. Bowie, John C. Wallace, Michael J. Tyler |
Abstract: | Eleven dahlein peptides are present in the skin secretion of the Australian aquatic frog Litoria dahlii. All peptides have been sequenced using a combination of electrospray mass spectrometry (ES-MS) and Lys-C digestion/MS, with each sequence confirmed by automated Edman sequencing. The 13-residue dahlein 1 peptides (e.g. dahlein 1.1 GLFDIIKNIVSTL-NH(2)) exhibit weak wide-spectrum antimicrobial activity but no significant activity in the anticancer testing program of the National Cancer Institute (Washington). There are no potent antimicrobial peptides present in the glandular secretion, but the dahleins 5 strongly inhibit the formation of NO by neuronal nitric oxide synthase (e.g. dahlein 5.1 GLLGSIGNAIGAFIANKLKP-OH). |
Keywords: | Animals Bufonidae Oligopeptides Chromatography, High Pressure Liquid Spectrometry, Mass, Electrospray Ionization Amino Acid Sequence Hydrolysis Molecular Sequence Data |
Description: | The definitive version may be found at www.wiley.com |
DOI: | 10.1002/rcm.429.abs |
Published version: | http://www3.interscience.wiley.com/cgi-bin/fulltext/85010855/PDFSTART |
Appears in Collections: | Aurora harvest 6 Chemistry publications |
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