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https://hdl.handle.net/2440/4848
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Type: | Journal article |
Title: | Negative ion fragmentations of deprotonated peptides: backbone cleavages directed through both Asp and Glu |
Author: | Brinkworth, C. Dua, S. Mc Anoy, A. Bowie, J. |
Citation: | Rapid Communications in Mass Spectrometry, 2001; 15(20):1965-1973 |
Publisher: | John Wiley & Sons Ltd |
Issue Date: | 2001 |
ISSN: | 0951-4198 1097-0231 |
Statement of Responsibility: | Craig S. Brinkworth, Suresh Dua, Andrew M. McAnoy, John H. Bowie |
Abstract: | The collision-induced spectra of [M - H](-) ions of a variety of natural and synthetic amphibian peptides containing Asp and/or Glu exhibit characteristic gamma backbone cleavage ions that identify the positions of these residues in the peptide. A theoretical study suggests that the Glu cleavage involves an S(N)i reaction of the carboxylate anion from the Glu alpha side chain to form a deprotonated cyclic lactone. The presence of either Asp or Glu or other residues that effect pronounced side-chain cleavages (e.g. Ser or Thr) results in the normal alpha and beta backbone cleavages being reduced in comparison to those cleavages which originate from side chains. |
Keywords: | Animals Anura Ions Aspartic Acid Glutamic Acid Peptides Spectrometry, Mass, Fast Atom Bombardment Amino Acid Sequence Elementary Particle Interactions Molecular Sequence Data Mass Spectrometry |
Description: | The definitive version may be found at www.wiley.com |
Provenance: | Published Online: 1 Oct 2001 |
DOI: | 10.1002/rcm.457 |
Grant ID: | ARC |
Published version: | http://www3.interscience.wiley.com/cgi-bin/fulltext/85514010/PDFSTART |
Appears in Collections: | Aurora harvest 6 Chemistry publications |
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