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https://hdl.handle.net/2440/4777
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Type: | Journal article |
Title: | Preparation and anti-tumour activity of some arylbismuth(III) oxine complexes |
Author: | Smith, Katharine A. Deacon, Glen B. Jackson, W. Roy Tiekink, Edward Richard Tom Rainone, Silvina Webster, Lorraine K. |
Citation: | Metal-Based Drugs. 5(5):295-304 |
Issue Date: | 1998 |
ISSN: | 0793-0291 |
School/Discipline: | School of Chemistry and Physics |
Statement of Responsibility: | Katharine A. Smith, Glen B. Deacon, W. Roy Jackson, Edward R. T. Tiekink, Silvina Rainone, and Lorraine K. Webster |
Abstract: | New arylbismuth(lll) oxinates, PhBi(MeOx)₂, (p-MeC₆H₄)Bi(Ox)₂, (p-MeC₆H₄)Bi(MeOx)₂, (p-ClC₆H4)Bi(Ox)₂, and (p-ClC₆H₄)Bi(MeOx)₂ (Ox− = quinolin-8-olate and MeOx−=2-methylquinolin-8-olate) have been prepared by reaction of the appropriate diarylbismuth chlorides with Na(Ox) or Na(MeOx) in the presence of 15-crown-5. An X-ray crystallographic study has shown PhBi(MeOx)₂ to be a five coordinate monomer with distorted square pyramidal stereochemistry. Chelating MeOx ligands have a cisoid arrangement in the square plane and the phenyl group is apical. The lattice is stabilised by significant π-π interactions between centrosymmetric molecules. A range of these complexes has been shown to have high in vitro biological activity (comparable with or better than cisplatin) against L1210 leukaemia, the corresponding cisplatin resistant line, and a human ovarian cell line, SKOV-3. However, initial in vivo testing against a solid mouse plasmacytoma (PC6) and P388 leukaemia has not revealed significant activity. |
DOI: | 10.1155/MBD.1998.295 |
Appears in Collections: | Chemistry publications |
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