Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/44523
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Type: | Journal article |
Title: | Nonlinear drift-diffusion model of gating in the fast Cl channel |
Author: | Vaccaro, Samuel Robert |
Citation: | Physical Review E, 2007; 76(1):011923 |
Publisher: | American Physical Society |
Issue Date: | 2007 |
ISSN: | 1539-3755 |
School/Discipline: | School of Chemistry and Physics : Physics and Mathematical Physics |
Statement of Responsibility: | S. R. Vaccaro |
Abstract: | The dynamics of the open or closed state region of an ion channel may be described by a probability density p(x,t) which satisfies a Fokker-Planck equation. The closed state dwell-time distribution fc(t) derived from the Fokker-Planck equation with a nonlinear diffusion coefficient D(x)∝exp(−γx), γ>0 and a linear ramp potential Uc(x), is in good agreement with experimental data and it may be shown analytically that if γ is sufficiently large, fc(t)∝t−2−ν for intermediate times, where ν=Uc′∕γ≈−0.3 for a fast Cl channel. The solution of a master equation which approximates the Fokker-Planck equation exhibits an oscillation superimposed on the power law trend and can account for an empirical rate-amplitude correlation that applies to several ion channels. |
Rights: | ©2007 American Physical Society |
DOI: | 10.1103/PhysRevE.76.011923 |
Appears in Collections: | Physics publications |
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