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https://hdl.handle.net/2440/44478
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Type: | Journal article |
Title: | Antimicrobial compounds from the Australian desert plant Eremophila neglecta |
Author: | Ndi, C. Semple, S. Griesser, H. Pyke, S. Barton, M. |
Citation: | Journal of Natural Products, 2007; 70(9):1439-1443 |
Publisher: | Amer Chemical Soc |
Issue Date: | 2007 |
ISSN: | 0163-3864 1520-6025 |
Statement of Responsibility: | Chi P. Ndi, Susan J. Semple, Hans J. Griesser, Simon M. Pyke, and Mary D. Barton |
Abstract: | A crude extract from the Australian desert plant Eremophila neglecta has recently been shown to possess antibacterial activity in a survey of candidate plants that may bear novel antimicrobial compounds. Bioassay-directed fractionation of the Et(2)O extract of E. neglecta using a broth microdilution assay led to the isolation of three new serrulatane-type diterpenoids, 2,19-diacetoxy-8-hydroxyserrulat-14-ene (2), 8,19-dihydroxyserrulat-14-ene (3), and 8-hydroxyserrulat-14-en-19-oic acid (4), and a known o-naphthoquinone commonly referred to as biflorin (5). The structures of 2-5 were determined using 1D and 2D NMR, FTIR, and high-resolution mass spectrometry. Compounds 3-5 showed antimicrobial activity against Gram-positive bacteria including Staphylococcus aureus, Streptococcus pyogenes, and S. pneumoniae. The minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) ranged from 6.5 to 101.6 microM and 12.7 to 202.9 microM, respectively. No activity was observed for these compounds against Gram-negative bacteria. |
Keywords: | Gram-Negative Bacteria Staphylococcus aureus Streptococcus pneumoniae Streptococcus pyogenes Eremophila Plant Plant Leaves Plants, Medicinal Diterpenes Anti-Infective Agents Microbial Sensitivity Tests Desert Climate Molecular Structure Australia |
Description: | Copyright © 2007 American Chemical Society and American Society of Pharmacognosy |
DOI: | 10.1021/np070180r |
Published version: | http://pubs.acs.org/cgi-bin/abstract.cgi/jnprdf/2007/70/i09/abs/np070180r.html |
Appears in Collections: | Aurora harvest Chemistry publications |
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