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Type: Journal article
Title: Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men
Author: Brennan, I.
Otto, B.
Feltrin, K.
Meyer, J.
Horowitz, M.
Feinle-Bisset, C.
Citation: Peptides, 2007; 28(3):607-611
Publisher: Elsevier Science Inc
Issue Date: 2007
ISSN: 0196-9781
Statement of
Ixchel M. Brennan, Bärbel Otto, Kate L. Feltrin, James H. Meyer, Michael Horowitz and Christine Feinle-Bisset
Abstract: We have investigated the effects of exogenous CCK-8 and GLP-1, alone and in combination, on ghrelin and PYY secretion. Nine healthy males were studied on four occasions. Plasma ghrelin and PYY concentrations were measured during 150 min intravenous infusions of: (i) isotonic saline, (ii) CCK-8 at 1.8 pmol/kg/min, (iii) GLP-1 at 0.9 pmol/kg/min or (iv) CCK-8 and GLP-1 combined. CCK-8 markedly suppressed ghrelin and stimulated PYY when compared with control between t=0-120 min (P<0.001 for both). GLP-1 had no effect on ghrelin, but decreased PYY slightly at 120 min (P<0.05). During infusion of CCK-8+GLP-1, there was comparable suppression of ghrelin (P<0.001), but the stimulation of PYY was less (P<0.001), than that induced by CCK-8, between t=20-120 min. In conclusion, in healthy subjects, in the doses evaluated, exogenous CCK-8 suppresses ghrelin and stimulates PYY, and exogenous GLP-1 has no effect on ghrelin and attenuates the effect of CCK-8 on PYY.
Keywords: Humans; Sincalide; Peptide YY; Peptide Hormones; Infusions, Intravenous; Adolescent; Adult; Male; Glucagon-Like Peptide 1; Ghrelin
Description: Copyright © 2006 Elsevier Inc. All rights reserved.
RMID: 0020070324
DOI: 10.1016/j.peptides.2006.10.014
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Appears in Collections:Medicine publications

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