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https://hdl.handle.net/2440/42228
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Type: | Journal article |
Title: | Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men |
Author: | Brennan, I. Otto, B. Feltrin, K. Meyer, J. Horowitz, M. Feinle-Bisset, C. |
Citation: | Peptides, 2007; 28(3):607-611 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2007 |
ISSN: | 0196-9781 1873-5169 |
Statement of Responsibility: | Ixchel M. Brennan, Bärbel Otto, Kate L. Feltrin, James H. Meyer, Michael Horowitz and Christine Feinle-Bisset |
Abstract: | We have investigated the effects of exogenous CCK-8 and GLP-1, alone and in combination, on ghrelin and PYY secretion. Nine healthy males were studied on four occasions. Plasma ghrelin and PYY concentrations were measured during 150 min intravenous infusions of: (i) isotonic saline, (ii) CCK-8 at 1.8 pmol/kg/min, (iii) GLP-1 at 0.9 pmol/kg/min or (iv) CCK-8 and GLP-1 combined. CCK-8 markedly suppressed ghrelin and stimulated PYY when compared with control between t=0-120 min (P<0.001 for both). GLP-1 had no effect on ghrelin, but decreased PYY slightly at 120 min (P<0.05). During infusion of CCK-8+GLP-1, there was comparable suppression of ghrelin (P<0.001), but the stimulation of PYY was less (P<0.001), than that induced by CCK-8, between t=20-120 min. In conclusion, in healthy subjects, in the doses evaluated, exogenous CCK-8 suppresses ghrelin and stimulates PYY, and exogenous GLP-1 has no effect on ghrelin and attenuates the effect of CCK-8 on PYY. |
Keywords: | Humans Sincalide Peptide YY Peptide Hormones Infusions, Intravenous Adolescent Adult Male Glucagon-Like Peptide 1 Ghrelin |
Description: | Copyright © 2006 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.peptides.2006.10.014 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/525495/description#description |
Published version: | http://dx.doi.org/10.1016/j.peptides.2006.10.014 |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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