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https://hdl.handle.net/2440/39385
Type: | Journal article |
Title: | Are cutaneous melanomas of specified thickness showing deeper levels of invasion at diagnosis? |
Author: | Luke, C. Coventry, B. Foster-Smith, E. Roder, D. |
Citation: | Asian Pacific Journal of Cancer Prevention (APJCP), 2003; 4(4):307-311 |
Publisher: | Asian Pacific Organization for Cancer Prevention |
Issue Date: | 2003 |
ISSN: | 1513-7368 2476-762X |
Statement of Responsibility: | Colin G. Luke, Brendon J. Coventry, Erwin J. Foster-Smith, David M. Roder |
Abstract: | Secular trends in Clark level were investigated by Breslow category for 8,432 invasive cutaneous melanomas diagnosed in South Australia in 1980-2000. More recently diagnosed lesions were found to have deeper levels. After adjusting for age at diagnosis, tumour site, histology, and thickness measured in half millimetres, the relative odds (95% confidence limits) of penetration to the reticular dermis or subcutaneous fat were 1.99 (1.59, 2.50) for the 1987- 93 diagnostic period, and 2.82 (2.25, 3.54) for 1994-2000, when compared with 1980-86. After adjusting for melanoma thickness, the secular trends for deeper lesions applied to a broad cross-section of socio-demographic sub-groups, tumour sites, and histological types. While this similarity in trend would be consistent with a measurement effect, a real change cannot be ruled out and increased emphasis on earlier detection may be warranted. The prognostic implications of changes in inter-relationships between measures of thickness and level require periodic re-evaluation. |
Keywords: | Cutaneous melanomas Clark level of invesion Breslow thickness Measurement effect |
Rights: | © Asian Pacific Organization for Cancer Prevention |
Published version: | http://www.apocp.org/cancer_download/Vol4_No4/Colin%20Luke.pdf |
Appears in Collections: | Aurora harvest 6 Surgery publications |
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