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Type: Journal article
Title: Enhanced apoptosis of soft tissue sarcoma cells with chemotherapy: A potential new approach using TRAIL
Author: Clayer, M.
Bouralexis, S.
Evdokiou, A.
Hay, S.
Atkins, G.
Findlay, D.
Citation: Journal of Orthopaedic Surgery, 2001; 9(2):19-22
Publisher: Hong Kong Academy of Medicine Press
Issue Date: 2001
ISSN: 1022-5536
Statement of
M Clayer, S Bouralexis, A Evdokiou, S Hay, GJ Atkins and DM Findlay
Abstract: Soft tissue sarcomas are less responsive to conventional chemotherapy when compared to bone sarcomas. We investigated the possibility of enhancing the efficacy of chemotherapy by utilising the recently identified cytokine, tumour necrosis factor-related apoptosis-inducing ligand (TRAIL/ Apo2L) in combination with standard chemotherapeutic agents. Fresh human soft tissue sarcomas (rhabdomyosarcoma, fibrosarcoma, malignant fibrous histiocytoma) were obtained at biopsy and dispersed tumour cells were incubated in cell culture with standard cytotoxic agents, either as single agents or in combination with TRAIL. The chemotherapeutic agents were, at best, moderately effective, in terms of induction of cellular apoptosis, although the fibrosarcoma was completely unresponsive to all single agents. TRAIL alone had no effect on any sarcoma cell culture. In contrast, the addition of TRAIL and drug together produced a significant increase in sarcoma cell apoptosis, with TRAIL and doxorubicin the most effective combination.
RMID: 0020071602
DOI: 10.1177/230949900100900205
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Appears in Collections:Orthopaedics and Trauma publications

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