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https://hdl.handle.net/2440/34802
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Type: | Journal article |
Title: | The Phosphoprotein StarD10 Is Overexpressed in Breast Cancer and Cooperates with ErbB Receptors in Cellular Transformation |
Author: | Olayioye, M. Hoffmann, P. Pomorski, T. Armes, J. Simpson, R. Kemp, B. Lindeman, G. Visvader, J. |
Citation: | Cancer Research, 2004; 64(10):3538-3544 |
Publisher: | Amer Assoc Cancer Research |
Issue Date: | 2004 |
ISSN: | 0008-5472 1538-7445 |
Statement of Responsibility: | Monilola A. Olayioye, Peter Hoffmann, Thomas Pomorski, Jane Armes, Richard J. Simpson, Bruce E. Kemp, Geoffrey J. Lindeman, and Jane E. Visvader |
Abstract: | We have identified that StarD10, a member of the START protein family, is overexpressed in both mouse and human breast tumors. StarD10 was initially discovered on the basis of its cross-reactivity with a phosphoserine-specific antibody in mammary tumors from Neu/ErbB2 transgenic mice and subsequently isolated from SKBR3 human breast carcinoma cells using a multistep biochemical purification strategy. We have shown that StarD10 is capable of binding lipids. StarD10 was found to be overexpressed in 35% of primary breast carcinomas and 64% of human breast cancer cell lines, correlating with their ErbB2/Her2 status. Coexpression of StarD10 with ErbB1/epidermal growth factor receptor in murine fibroblasts enhanced anchorage-independent growth in soft agar, providing evidence for functional cooperation between StarD10 and ErbB receptor signaling. Taken together, these data suggest that overexpression of this lipid-binding protein contributes to breast oncogenesis. |
Keywords: | Cell Line, Tumor Animals Humans Mice Breast Neoplasms Mammary Neoplasms, Experimental Cell Transformation, Neoplastic Receptor, erbB-2 Phosphoproteins Transcription Factors Antibody Specificity Cross Reactions Amino Acid Sequence Sequence Homology, Amino Acid Molecular Weight Molecular Sequence Data Forkhead Transcription Factors ErbB Receptors Forkhead Box Protein O1 |
DOI: | 10.1158/0008-5472.CAN-03-3731 |
Published version: | http://cancerres.aacrjournals.org/cgi/content/abstract/64/10/3538 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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