Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/34797
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Grutzner, F. | - |
dc.contributor.author | Crollius, H. | - |
dc.contributor.author | Lutjens, G. | - |
dc.contributor.author | Weissenbach, J. | - |
dc.contributor.author | Ropers, H. | - |
dc.contributor.author | Haaf, T. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Genome Research, 2002; 12(9):1316-1322 | - |
dc.identifier.issn | 1088-9051 | - |
dc.identifier.issn | 1549-5469 | - |
dc.identifier.uri | http://hdl.handle.net/2440/34797 | - |
dc.description | Copyright ©2002 by Cold Spring Harbor Laboratory Press | - |
dc.description.abstract | The freshwater pufferfish Tetraodon nigroviridis (TNI) has become highly attractive as a compact reference vertebrate genome for gene finding and validation. We have mapped genes, which are more or less evenly spaced on the human chromosomes 9 and X, on Tetraodon chromosomes using fluorescence in situ hybridization (FISH), to establish syntenic relationships between Tetraodon and other key vertebrate genomes. PufferFISH revealed that the human X is an orthologous mosaic of three Tetraodon chromosomes. More than 350 million years ago, an ancestral vertebrate autosome shared orthologous Xp and Xq genes with Tetraodon chromosomes 1 and 7. The shuffled order of Xp and Xq orthologs on their syntenic Tetraodon chromosomes can be explained by the prevalence of evolutionary inversions. The Tetraodon 2 orthologous genes are clustered in human Xp11 and represent a recent addition to the eutherian X sex chromosome. The human chromosome 9 and the avian Z sex chromosome show a much lower degree of synteny conservation in the pufferfish than the human X chromosome. We propose that a special selection process during vertebrate evolution has shaped a highly conserved array(s) of X-linked genes long before the X was used as a mammalian sex chromosome and many X chromosomal genes were recruited for reproduction and/or the development of cognitive abilities. | - |
dc.description.statementofresponsibility | Frank Grutzner, Hugues Roest Crollius, Gotz Lutjens, Olivier Jaillon, Jean Weissenbach, Hans-Hilger Ropers, and Thomas Haaf | - |
dc.language.iso | en | - |
dc.publisher | Cold Spring Harbor Lab Press | - |
dc.source.uri | http://dx.doi.org/10.1101/gr.222402 | - |
dc.subject | Chromosomes, Human, Pair 9 | - |
dc.subject | X Chromosome | - |
dc.subject | Animals | - |
dc.subject | Chickens | - |
dc.subject | Tetraodontiformes | - |
dc.subject | Humans | - |
dc.subject | DNA | - |
dc.subject | Genetic Markers | - |
dc.subject | Evolution, Molecular | - |
dc.subject | Conserved Sequence | - |
dc.subject | Synteny | - |
dc.subject | Genes | - |
dc.subject | Molecular Sequence Data | - |
dc.title | Four-Hundred Million Years of Conserved Synteny of Human Xp and Xq Genes on Three Tetraodon Chromosomes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1101/gr.222402 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Grutzner, F. [0000-0002-3088-7314] | - |
Appears in Collections: | Aurora harvest Environment Institute Leaders publications Molecular and Biomedical Science publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_34797.pdf | 414.11 kB | Publisher's PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.