Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/28194
Type: | Journal article |
Title: | The structure and function of vertebrate fibroblast growth factor receptor 1 |
Author: | Groth, C. Lardelli, M. |
Citation: | The International Journal of Developmental Biology, 2002; 46(4 Special Issue SI):393-400 |
Publisher: | Univ Basque Country Press |
Issue Date: | 2002 |
ISSN: | 0214-6282 1696-3547 |
Organisation: | Centre for the Molecular Genetics of Development |
Statement of Responsibility: | Casper Groth and Michael Lardelli |
Abstract: | The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. The restricted expression patterns of FGFR1 isoforms, together with differential expression and binding of specific ligands, leads to activation of common FGFR1 signal transduction pathways, but may result in distinctively different biological responses as a result of differences in cellular context. FGFR1 isoforms are also present in the nucleus in complex with various fibroblast growth factors where they function to regulate transcription of target genes. |
Keywords: | fibroblast growth factor receptor fibroblast growth factor signal transduction Notch vertebrate |
Rights: | © UBC Press |
Published version: | http://www.ijdb.ehu.es/web/paper.php?doi=12141425 |
Appears in Collections: | Aurora harvest 6 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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hdl_28194.pdf | 328.11 kB | Publisher's PDF | View/Open |
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