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https://hdl.handle.net/2440/28019
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Type: | Journal article |
Title: | A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans |
Author: | Paton, A. Morona, R. Paton, J. |
Citation: | Nature Medicine, 2000; 6(3):265-270 |
Publisher: | Nature Publishing Group |
Issue Date: | 2000 |
ISSN: | 1078-8956 1546-170X |
Abstract: | Gastrointestinal disease caused by Shiga toxin-producing bacteria (such as Escherichia coli O157:H7 and Shigella dysenteriae) is often complicated by life-threatening toxin-induced systemic sequelae, including hemolytic-uremic syndrome. Such infections can now be diagnosed very early in the course of the disease, but at present no effective therapeutic intervention is possible. Here, we constructed a recombinant bacterium that displayed a Shiga toxin receptor mimic on its surface, and it adsorbed and neutralized Shiga toxins with very high efficiency. Moreover, oral administration of the recombinant bacterium completely protected mice from challenge with an otherwise 100%-fatal dose of Shiga toxigenic E. coli. Thus, the bacterium shows great promise as a 'probiotic' treatment for Shiga toxigenic E. coli infections and dysentery. |
Keywords: | Animals Humans Mice Escherichia coli O157 Shigella dysenteriae Dysentery, Bacillary Escherichia coli Infections Guanylate Cyclase Galactosyltransferases Escherichia coli Proteins Receptors, Peptide Recombinant Proteins Bacterial Toxins Shiga Toxins Enterotoxins Cloning, Molecular Recombination, Genetic Carbohydrate Sequence Molecular Sequence Data Receptors, Guanylate Cyclase-Coupled Receptors, Enterotoxin |
DOI: | 10.1038/73111 |
Published version: | http://dx.doi.org/10.1038/73111 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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