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https://hdl.handle.net/2440/27485
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Type: | Journal article |
Title: | 13C-Urea breath test: Reproducibility and association with the severity of Helicobacter pylori-associated antral gastritis |
Author: | Matthews, G. Cummins, A. Lawrence, A. Johnson, B. Campbell, F. Butler, R. |
Citation: | Journal of Gastroenterology and Hepatology, 2005; 20(2):270-274 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2005 |
ISSN: | 0815-9319 1440-1746 |
Statement of Responsibility: | Matthews, Geoffrey M; Cummins, Adrian G; Lawrence, Andrew; Johnson, Bruce; Campbell, Fiona; Butler, Ross N |
Abstract: | <h4>Background</h4>The purpose of the present paper was to assess the reproducibility of the (13)C-urea breath test ((13)C-UBT) and its ability to reflect the level of Helicobacter pylori-associated inflammation.<h4>Methods</h4>Asymptomatic H. pylori-positive subjects (n = 21) performed the (13)C-UBT six times. The H. pylori-positive symptomatic subjects (n = 55) performed the (13)C-UBT and had antral biopsies taken for histopathology, culture, urease activity assay and myeloperoxidase activity assay.<h4>Results</h4>No significant intraindividual variation in (13)C-UBT results were observed for the asymptomatic subjects. The (13)C-UBT results were significantly higher in symptomatic subjects with a moderate to severe gastritis compared to a mild gastritis and to no inflammation (34.5 +/- 4.4 vs 17.7 +/- 2.8 vs 1.7 +/- 0.1, respectively, P < 0.01). The (13)C-UBT results significantly correlated with urease (r = 0.55) and myeloperoxidase activity (r = 0.82) but not with bacterial load. conclusion: The (13)C-UBT is a reproducible determinant of H. pylori infection and non-invasively assesses the severity of antral inflammation. |
Keywords: | Humans Helicobacter pylori Helicobacter Infections Urea Peroxidase Breath Tests Gastroscopy Severity of Illness Index Sensitivity and Specificity Reproducibility of Results Adolescent Adult Aged Aged, 80 and over Middle Aged Female Male |
DOI: | 10.1111/j.1440-1746.2005.03547.x |
Published version: | http://dx.doi.org/10.1111/j.1440-1746.2005.03547.x |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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