Adelaide Research & Scholarship
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https://hdl.handle.net/2440/22732
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| Type: | Journal article |
| Title: | Synthesis and biological activity of allosteric modulators of GABA(B) receptors, Part 1. N-(phenylpropyl)-1-arylethylamines |
| Author: | Kerr, D. Ong, J. Perkins, M. Prager, R. Puspawati, N. |
| Citation: | Australian Journal of Chemistry: an international journal for chemical science, 2006; 59(7):445-456 |
| Publisher: | C S I R O Publishing |
| Issue Date: | 2006 |
| ISSN: | 0004-9425 |
| Abstract: | <jats:p> A series of 15 analogues of fendiline, and 34 derivatives of N-(3-phenylpropyl)-1-arylethylamine have been prepared for evaluation as positive allosteric modulators of GABAB receptors. The most active (EC50, 10 nM) was N-(3,3-diphenylpropyl)-1-(3-chloro-4-methoxyphenyl)ethylamine 6g. </jats:p> |
| DOI: | 10.1071/CH06163 |
| Published version: | http://dx.doi.org/10.1071/ch06163 |
| Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 2 |
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