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https://hdl.handle.net/2440/1616
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Type: | Journal article |
Title: | The use of allozyme electrophoresis to assess genetic heterogeneity among previously subspeciated isolates of Fusobacterium nucleatum |
Author: | Morris, M. Andrews, R. Rogers, A. |
Citation: | Molecular Oral Microbiology, 1996; 11(1):15-21 |
Publisher: | MUNKSGAARD INT PUBL LTD |
Issue Date: | 1996 |
ISSN: | 0902-0055 1399-302X |
Abstract: | Fusobacterium nucleatum has been implicated in the pathogenesis of periodontal diseases. Five subspecies have previously been proposed. The validity of these subdivisions was investigated using allozyme electrophoresis for 21 enzyme mobilities. The 18 F. nucleatum isolates tested had previously been subspeciated and included type strains as well as isolates from both oral and extraoral sites. The results showed 2 distinct genetic groups with fixed differences at 82.5% of the test loci, indicative of a species complex with a number of subspecies within each of the 2 groups. There was also evidence of a correlation between the 2 major groups of isolates and the site from which they were taken. It was concluded that there is a high degree of genetic heterogeneity within the species F. nucleatum and that its current subspeciation is of questionable validity. |
Keywords: | Humans Fusobacterium nucleatum Abscess Electrophoresis, Cellulose Acetate Bacterial Typing Techniques Phenotype Genetic Heterogeneity Alleles Genetic Variation |
DOI: | 10.1111/j.1399-302X.1996.tb00331.x |
Description (link): | http://www.ncbi.nlm.nih.gov/pubmed/8604250 |
Published version: | http://dx.doi.org/10.1111/j.1399-302x.1996.tb00331.x |
Appears in Collections: | Aurora harvest 2 Dentistry publications |
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