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https://hdl.handle.net/2440/1485
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Type: | Journal article |
Title: | Is medication a risk factor for dental caries among older people? Evidence from a longitudinal study in South Australia |
Author: | Thomson, W. Spencer, A. Slade, G. Chalmers, J. |
Citation: | Community Dentistry and Oral Epidemiology, 2002; 30(3):224-232 |
Publisher: | Munksgaard Int Publ Ltd |
Issue Date: | 2002 |
ISSN: | 0301-5661 1600-0528 |
Statement of Responsibility: | W. Murray Thomson, A. John Spencer, Gary D Slade and Jane M Chalmer |
Abstract: | Objectives: This study examined the association between chronic medication exposure and 5-year dental caries increment among older people, using a theoretical model whereby xerogenic medication is thought to lead to increased caries by either (i) chronically lowering salivary flow, thus reducing salivary buffering of plaque acids, or (ii) producing the symptoms of dry mouth, leading to symptomatic relief through the use of cariogenic drinks and foodstuffs. Methods: Data were obtained from participants remaining at the 5-year follow-up phase of a cohort study of community-dwelling South Australians aged 60¹. Medication information was available at baseline and at 5 years, enabling only those medications taken on both occasions to be included in the analyses. Dental examinations were conducted at baseline and 5 years, and a reversal-adjusted 5- year caries increment was computed. Multivariate modelling was used to control the effects of potential confounders. Results: Of the original sample, 528 (62.3%) remained after 5years, with those remaining tending to be younger, healthier and less medicated than those lost to follow-up. Five-year coronal caries incidence was 66.9%. The adjusted coronal caries increment (AdjCI) was higher among males and among those taking a b-blocker or an antiasthma drug for the previous 5 years. The 5-year incidence of root surface caries was 59.3%. A lower root surface AdjCI was associated with taking daily aspirin. Of the medications shown in earlier analyses to predict dry mouth, only the antiasthma drugs were associated with higher caries experience, and they had predicted more severe zerostomia symptoms. Conclusions: This study offers no strong evidence for a medication-caries relationship, as only one of the observed medication-caries associations was explicable in terms of the theoretical model. However, it should be acknowledged that older people taking antiasthma drugs may be at higher risk of coronal caries, possibly through measures taken for the symptomatic relief of dry mouth. |
Keywords: | cohort study dental caries elderly medication |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1034/j.1600-0528.2002.300309.x |
Published version: | http://dx.doi.org/10.1034/j.1600-0528.2002.300309.x |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
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