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https://hdl.handle.net/2440/14327
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Type: | Journal article |
Title: | The nasal airways response in normal subjects to oxymetazoline spray: randomized double-blind placebo-controlled trial |
Author: | Bickford, L. Shakib, S. Taverner, D. |
Citation: | British Journal of Clinical Pharmacology, 1999; 48(1):53-56 |
Publisher: | BLACKWELL SCIENCE LTD |
Issue Date: | 1999 |
ISSN: | 0306-5251 1365-2125 |
Statement of Responsibility: | Bickford, Larissa ; Shakib, Sepehr ; Taverner, David |
Abstract: | <h4>Aims</h4>The effects of a single dose of oxymetazoline nasal spray on nasal patency have been compared with placebo using three separate measuring systems in normal subjects.<h4>Methods</h4>The study was a placebo-controlled, randomised double-blind crossover trial. Subjects without ear, nose or throat disease and with resting nasal airways resistance >0.15 Pa s cm-3 were selected so that a fall in airways resistance could be detected. Nasal airways resistance (NAR) was measured by NR6-2 rhinomanometer. Acoustic rhinometry (SR-2000 rhinometer) provided the sum of the minimum cross-sectional areas (tMCA) and volume (tVOL) of the left and right nasal cavities. Symptoms of congestion were assessed on a visual analogue scale (CON, range 0-100). Measurements were made for 60 min before and for 120 min after bilateral administration of oxymetazoline nasal spray (0.9 mg) or placebo (0.9% saline). Crossover occurred 7-21 days later. Results for all measures were analysed as change from average baseline value by trapezoidal AUC, and statistical significance was tested by 2-way anova.<h4>Results</h4>NAR, tMCA, tVOL and CON did not change after placebo, but NAR and CON fell and tMCA and tVOL increased significantly at all timepoints after oxymetazoline. NAR_AUC, tVOL_AUC, tMCA_AUC were significantly different between placebo and oxymetazoline (P<0.001) as was CON_AUC (P=0.012). The day-to-day intraindividual repeatability of baseline NAR tMCA and tVOL was <10%.<h4>Conclusions</h4>Normal subjects can be used to detect the effects of nasally vasoactive drugs with a variety of complementary systems, with the advantages of easy subject recruitment and low variability. |
Keywords: | Nasal Mucosa Humans Oxymetazoline Nasal Decongestants Aerosols Cross-Over Studies Double-Blind Method Adult Female Male Outcome and Process Assessment, Health Care |
DOI: | 10.1046/j.1365-2125.1999.00972.x |
Published version: | http://dx.doi.org/10.1046/j.1365-2125.1999.00972.x |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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