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https://hdl.handle.net/2440/139166
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Type: | Journal article |
Title: | Associations of dietary patterns, ultra-processed food and nutrient intake with incident atrial fibrillation |
Author: | Tu, S.J. Gallagher, C. Elliott, A.D. Bradbury, K.E. Marcus, G.M. Linz, D. Pitman, B.M. Middeldorp, M.E. Hendriks, J.M. Lau, D.H. Sanders, P. Wong, C.X. |
Citation: | Heart, 2023; 109(22):1683-1689 |
Publisher: | BMJ |
Issue Date: | 2023 |
ISSN: | 1355-6037 1468-201X |
Statement of Responsibility: | Samuel J Tu, Celine Gallagher, Adrian D Elliott, Kathryn E Bradbury, Gregory M Marcus, Dominik Linz, Bradley M Pitman, Melissa E Middeldorp, Jeroen M Hendriks, Dennis H Lau, Prashanthan Sanders, Christopher X Wong |
Abstract: | OBJECTIVE: To examine the associations between specific dietary patterns and incident atrial fibrillation (AF). METHODS: Using data from the UK Biobank, dietary intakes were calculated from 24-hour diet recall questionnaires. Indices representing adherence to dietary patterns (Mediterranean-style, Dietary Approaches to Stop Hypertension (DASH) and plant-based diets) were scored, and ultra-processed food consumption was studied as a percentage of total food mass consumed. Incident AF hospitalisations were assessed in Cox regression models. RESULTS: A total of 121 300 individuals were included, with 4 579 incident AF cases over a median follow-up of 8.8 years. Adherence to Mediterranean-style or DASH diets was associated with a lower incidence of AF in minimally adjusted analyses (HR for highest vs lowest quintile 0.87 (95% CI 0.80-0.96) and HR 0.78 (95% CI 0.71-0.86), respectively). However, associations were no longer significant after accounting for lifestyle factors (HR 0.95 (95% CI 0.87-1.04) and 0.94 (95% CI 0.86-1.04) respectively), with adjustment for body mass index responsible for approximately three-quarters of the effect size attenuation. Plant-based diets were not associated with AF risk in any models. Greatest ultra-processed food consumption was associated with a significant increase in AF risk even in fully adjusted models (HR 1.13 (95% CI 1.02-1.24)), and a 10% increase in absolute intake of ultra-processed food was associated with a 5% increase in AF risk (HR 1.05 (95% CI 1.01-1.08)). CONCLUSION: With the possible exception of reducing ultra-processed food consumption, these findings suggest that attention to other modifiable risk factors, particularly obesity, may be more important than specific dietary patterns for the primary prevention of AF. |
Keywords: | atrial fibrillation epidemiology risk factors |
Description: | Published Online First 17 July 2023 |
Rights: | © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ. |
DOI: | 10.1136/heartjnl-2023-322412 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1136/heartjnl-2023-322412 |
Appears in Collections: | Medicine publications |
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