Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/135149
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| Type: | Journal article |
| Title: | Harnessing the chemokine system to home CAR-T cells into solid tumors |
| Author: | Foeng, J. Comerford, I. McColl, S.R. |
| Citation: | Cell Reports Medicine, 2022; 3(3):100543-1-100543-15 |
| Publisher: | Elsevier BV |
| Issue Date: | 2022 |
| ISSN: | 2666-3791 2666-3791 |
| Statement of Responsibility: | Jade Foeng, Iain Comerford, and Shaun R. McColl |
| Abstract: | CAR-T cell therapy has been heralded as a breakthrough in the field of immunotherapy, but to date, this suc- cess has been limited to hematological malignancies. By harnessing the chemokine system and taking into consideration the chemokine expression profile in the tumor microenvironment, CAR-T cells may be homed into tumors to facilitate direct tumor cell cytolysis and overcome a major hurdle in generating effective CAR-T cell responses to solid cancers. |
| Keywords: | T-Lymphocytes Humans Neoplasms Receptors, Antigen, T-Cell Chemokines Immunotherapy, Adoptive Tumor Microenvironment |
| Rights: | © 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| DOI: | 10.1016/j.xcrm.2022.100543 |
| Grant ID: | http://purl.org/au-research/grants/nhmrc/1030247 http://purl.org/au-research/grants/nhmrc/1105312 |
| Published version: | http://dx.doi.org/10.1016/j.xcrm.2022.100543 |
| Appears in Collections: | Microbiology and Immunology publications |
Files in This Item:
| File | Description | Size | Format | |
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| hdl_135149.pdf | Published version | 1.75 MB | Adobe PDF | View/Open |
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