Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/134581
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Type: | Journal article |
Title: | Double-clad fiber-based multifunctional biosensors and multimodal bioimaging systems: technology and applications |
Author: | Beaudette, K. Li, J. Lamarre, J. Majeau, L. Boudoux, C. |
Citation: | Biosensors, 2022; 12(2):90-1-90-18 |
Publisher: | MDPI AG |
Issue Date: | 2022 |
ISSN: | 2079-6374 2079-6374 |
Statement of Responsibility: | Kathy Beaudette, Jiawen Li, Joseph Lamarre, Lucas Majeau and Caroline Boudoux |
Abstract: | Optical fibers have been used to probe various tissue properties such as temperature, pH, absorption, and scattering. Combining different sensing and imaging modalities within a single fiber allows for increased sensitivity without compromising the compactness of an optical fiber probe. A double-clad fiber (DCF) can sustain concurrent propagation modes (single-mode, through its core, and multimode, through an inner cladding), making DCFs ideally suited for multimodal approaches. This study provides a technological review of how DCFs are used to combine multiple sensing functionalities and imaging modalities. Specifically, we discuss the working principles of DCF-based sensors and relevant instrumentation as well as fiber probe designs and functionalization schemes. Secondly, we review different applications using a DCF-based probe to perform multifunctional sensing and multimodal bioimaging. |
Keywords: | Biosensor; double-clad fiber; fluorescence; multimodal imaging; multi-photon imaging; optical coherence tomography; pH sensing; spectroscopy; temperature sensing |
Rights: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/bios12020090 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/2001646 http://purl.org/au-research/grants/nhmrc/GNT2008462 |
Published version: | http://dx.doi.org/10.3390/bios12020090 |
Appears in Collections: | Electrical and Electronic Engineering publications |
Files in This Item:
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hdl_134581.pdf | Published version | 15.65 MB | Adobe PDF | View/Open |
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