Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/134075
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Type: | Journal article |
Title: | Intergenerational effects of a paternal Western diet during adolescence on offspring gut microbiota, stress reactivity, and social behavior |
Author: | Bodden, C. Pang, T.Y. Feng, Y. Mridha, F. Kong, G. Li, S. Watt, M.J. Reichelt, A.C. Hannan, A.J. |
Citation: | The FASEB Journal, 2022; 36(1):e21981-1-e21981-22 |
Publisher: | Federation of American Society of Experimental Biology |
Issue Date: | 2022 |
ISSN: | 0892-6638 1530-6860 |
Statement of Responsibility: | Carina Bodden, Terence Y. Pang, Yingshi Feng, Faria Mridha, Geraldine Kong, Shanshan Li ... et al. |
Abstract: | The global consumption of highly processed, calorie-dense foods has contributed to an epidemic of overweight and obesity, along with negative consequences for metabolic dysfunction and disease susceptibility. As it becomes apparent that overweight and obesity have ripple effects through generations, understanding of the processes involved is required, in both maternal and paternal epigenetic inheritance. We focused on the patrilineal effects of a Western-style high-fat (21%) and high-sugar (34%) diet (WD) compared to control diet (CD) during adolescence and investigated F0 and F1 mice for physiological and behavioral changes. F0 males (fathers) showed increased body weight, impaired glycemic control, and decreased attractiveness to females. Paternal WD caused significant phenotypic changes in F1 offspring, including higher body weights of pups, increased Actinobacteria abundance in the gut microbiota (ascertained using 16S microbiome profiling), a food preference for WD pellets, increased male dominance and attractiveness to females, as well as decreased behavioral despair. These results collectively demonstrate the long-term intergenerational effects of a Western-style diet during paternal adolescence. The behavioral and physiological alterations in F1 offspring provide evidence of adaptive paternal programming via epigenetic inheritance. These findings have important implications for understanding paternally mediated intergenerational inheritance, and its relevance to offspring health and disease susceptibility. |
Keywords: | behavioral phenotyping epigenetic inheritance gut microbiome high-fat high-sugar diet intergenerational inheritance paternal effects |
Rights: | © 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
DOI: | 10.1096/fj.202100920RR |
Grant ID: | http://purl.org/au-research/grants/arc/DP180101974 NHMRC |
Published version: | http://dx.doi.org/10.1096/fj.202100920rr |
Appears in Collections: | Medicine publications |
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hdl_134075.pdf | Published version | 2.78 MB | Adobe PDF | View/Open |
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