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https://hdl.handle.net/2440/133529
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Type: | Journal article |
Title: | High-resolution colonic motility recordings in vivo compared with ex vivo recordings after colectomy, in patients with slow transit constipation |
Author: | Dinning, P.G. Sia, T.C. Kumar, R. Mohd Rosli, R. Kyloh, M. Wattchow, D.A. Wiklendt, L. Brookes, S.J.H. Costa, M. Spencer, N.J. |
Citation: | Neurogastroenterology and Motility, 2016; 28(12):1824-1835 |
Publisher: | Wiley |
Issue Date: | 2016 |
ISSN: | 1350-1925 1365-2982 |
Statement of Responsibility: | P. G. Dinning, T. C. Sia, R. Kumar, R. Mohd Rosli, M. Kyloh, D. A. Wattchow, L. Wiklendt, S. J. H. Brookes, M. Costa, N. J. Spencer |
Abstract: | Background The pathogenesis of slow transit constipation (STC) remains poorly understood, with intrinsic and extrinsic abnormalities implicated. Here, we present high-resolution colonic manometry recordings from four STC patients recorded before total colectomy, and subsequently, ex vivo, after excision. Methods In four female, treatment-resistant STC patients (median age 35.5 years), a fiber-optic manometry catheter (72 sensors spaced at 1 cm intervals) was placed with the aid of a colonoscope, to the midtransverse colon. Colonic manometry was recorded 2 h before and after a meal. After the colectomy, ex vivo colonic manometry was recorded in an organ bath. Ex vivo recordings were also made from colons from 4 patients (2 male; median age 67.5 years) undergoing anterior resection for nonobstructive carcinoma (‘control’ tissue). Key Results A large increase in ‘short single propagating contractions’ was recorded in STC colon ex vivo compared to in vivo (ex vivo 61.3 32.7 vs in vivo 2.5 5/h). In STC patients, in vivo, the dominant frequency of contractile activity was 2–3 cycle per minute (cpm), whereas 1-cpm short-single propagating contractions dominated ex vivo. This same 1-cpm frequency was also dominant in control colons ex vivo. Conclusions & Inferences In comparison to control adults, the colon of STC patients demonstrates significantly less propagating motor activity. However, once the STC colon is excised from the body it demonstrates a regular and similar frequency of propagating activity to control tissue. This paper provides interesting insights into the control of colonic motor patterns. |
Keywords: | colectomy; constipation; ex vivo motility; high-resolution manometry |
Rights: | © 2016 John Wiley & Sons Ltd |
DOI: | 10.1111/nmo.12884 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1064835 |
Published version: | http://dx.doi.org/10.1111/nmo.12884 |
Appears in Collections: | Medicine publications |
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